Author
D. F. Ewing
Bio: D. F. Ewing is an academic researcher from National Research Council. The author has contributed to research in topics: Vicinal & Cis–trans isomerism. The author has an hindex of 3, co-authored 3 publications receiving 37 citations.
Papers
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TL;DR: In this paper, a small amount of C6H18O5 was found in the seed oil of Cardiospermum halicacabum L. The molecular weight was confirmed by the mass spectrum.
15 citations
TL;DR: In this article, a 2-phenylbenzofuranoid compound of known structure was obtained from the seed oil of Styrax americana Lam, and the nuclear magnetic resonance spectra of egonol and 3-nitroegonol were examined.
Abstract: Egonol, a 2-phenylbenzofuranoid compound of known structure, was obtained from the seed oil of Styrax americana Lam. The nuclear magnetic resonance spectra of egonol and 3-nitroegonol were examined, and all of the proton signals were assigned. Egonoic acid and egonyl chloroacetate were prepared; their ultraviolet, infrared, and nuclear magnetic resonance spectra confirmed the structure of egonol. The content of egonol in oils may be estimated from the intensity of specified bands in the spectra.
12 citations
TL;DR: Racemic threo-9,10,dihydroxypalmitic acid was resolved by means of the brucine salts into the optically active forms Levorotatory threeso-11,12,dhydroxyeicosanoic acid as discussed by the authors.
Abstract: Racemic threo-9,10-dihydroxypalmitic acid was resolved by means of the brucine salts into the optically active forms Levorotatory threo-11,12-dihydroxyeicosanoic acid was obtained from the corresp
11 citations
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TL;DR: Assessing enzyme inhibition in an isolated rat liver mitochondrial system, TDGA- coA (synthetic or enzyme prepared) was more potent than TDGA or MeTDGA and retained activity in the absence of CoA or Mg2+-ATP and inhibited palmitoyl-CoA but not palmitoysl carnitine oxidation.
141 citations
TL;DR: This review aims to highlight the origins, structures, biological potencies, and synthetic approaches of those natural products bearing at least one benzofuran in their complex structures and especially focus on the step in which this key heterocycle is installed during the total synthesis of a natural product as the desired target.
Abstract: Research on natural products containing benzofuran has remarkably increased during the past few decades. Newly isolated natural products with complex structures are being studied, characterized and screened for possible biological activities. Several of such compounds have exhibited various biological activities, thus their total syntheses have attracted much attention from synthetic organic chemists. In this review, we aim to highlight the origins, structures, biological potencies, and synthetic approaches of those natural products bearing at least one benzofuran in their complex structures. Furthermore, we especially focus on the step in which this key heterocycle is installed during the total synthesis of a natural product as the desired target.
111 citations
Metz1
TL;DR: A review of the recent advances in the chemistry of benzo[b]furan and its derivatives can be found in this article, where the presence of benzofurans in coal tar and in petroleum is discussed.
Abstract: Publisher Summary The chapter focuses on the recent advances in the chemistry of benzo[b]furan and its derivatives. The chemistry of benzofuran derivatives has developed in a spectacular fashion: research in this field has reached such a scale that the period covered by this review has given rise to a larger number of papers than that between 1870 and 1950. It has proceeded along the following three main lines: (1) Extraction, determination of structures, partial or total synthesis of the simple or complex heterocyclic derivatives constituting the natural benzofuran derivatives of vegetable origin. (2) Synthesis of benzofuran derivatives with physiological, pharmacological, therapeutic, or toxic properties. (3) Studies on the reactivity of benzofuran and its derivatives from the chemical and physical point of view. Many substances with physiological, pharmacological, therapeutic, or toxic properties are to be found among natural products with a benzofuran ring. As to synthetic benzofuran derivatives prepared for the study of their physiological properties, their number is large. Benzofuran is prepared in semicommercial amounts. The chapter discusses the presence of benzofurans in coal tar and in petroleum. Natural benzofuran derivatives have also been discussed. The numerous syntheses of the benzofuran ring may be classified under four headings: (1) Formation of the heterocyclic ring from an aromatic substrate (2) formation of the heterocyclic ring from a nonaromatic substrate (3) fusion of the benzene ring to a furan substrate (4) formation of the heterocyclic ring from other heterocyclic compounds.
93 citations
TL;DR: In this article, the antidiarrhoeal activity of whole plant extracts of Cardiospermum halicacabum (Linn) in rats was evaluated using LD50 studies up to the dose limit of 2000 mg/kg.
Abstract: Objective: To evaluate the antidiarrhoeal activity of whole plant extracts of Cardiospermum halicacabum (Linn) in rats. Materials and Methods: Petroleum ether (PeCH) and alcoholic (AlCH) extracts of whole plant of Cardiospermum halicacabum (Linn) were prepared, with successive extraction in soxhlet apparatus and aqueous (AqCH) extract, by the maceration process. LD50 studies for all the three extracts were carried out up to the dose limit of 2000 mg/kg in albino mice. One-fifth of the maximum dose of LD50 of each extract was selected to study the antidiarrhoeal activity in different experimental models such as castor oil-induced diarrhoea, prostaglandin E2 (PGE2)-induced enteropooling and charcoal meal test in rats. Results: Preliminary phytochemical studies revealed the presence of sterols, carbohydrates, tannins and triterpenes in the PeCH extract; sterols, saponins, carbohydrates, flavonoids and tannins in the AlCH extract; sterols, saponins, carbohydrates, flavonoids and tannins in the AqCH extract. No mortality was observed with any of the three extracts up to the maximum dose of 2000 mg/kg. Further, all the three extracts at 400 mg/kg, p.o . had significantly ( P Conclusion: The present study revealed the antidiarrhoeal activity of the extracts of Cardiospermum halicacabum, which may be due to the presence of phytochemical constituents such as sterols, tannins, flavonoids and triterpenes.
51 citations