D
D Ford
Researcher at Institute of Cancer Research
Publications - 31
Citations - 13467
D Ford is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 25, co-authored 31 publications receiving 13159 citations.
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Journal ArticleDOI
Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families
D Ford,Douglas F. Easton,Michael R. Stratton,Steven A. Narod,David E. Goldgar,Peter Devilee,D. T. Bishop,Barbara L. Weber,Gilbert M. Lenoir,Jenny Chang-Claude,Hagay Sobol,M D Teare,Jeffery P. Struewing,Adalgeir Arason,Siegfried Scherneck,Julian Peto,Timothy R. Rebbeck,Patricia N. Tonin,Susan L. Neuhausen,Rosa B. Barkardottir,Jorunn E. Eyfjord,Henry T. Lynch,Bruce A.J. Ponder,Simon A. Gayther,J.M. Birch,Annika Lindblom,Dominique Stoppa-Lyonnet,Y. J. Bignon,Åke Borg,U Hamann,Neva E. Haites,Rodney J. Scott,Christine Maugard,Hans F. A. Vasen,Susanne Seitz,Lisa A. Cannon-Albright,Andrew Craig Schofield,Moraima Zelada-Hedman +37 more
TL;DR: The lifetime risk of breast cancer appears similar to the risk in BRCA1 carriers, but there was some suggestion of a lower risk in bRCA2 carriers <50 years of age.
Journal ArticleDOI
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Richard Wooster,Susan L. Neuhausen,Jonathan Mangion,Yvette Quirk,D Ford,N. Collins,K. Nguyen,Sheila Seal,T.D. Tran,D. Averill,P Fields,Gill Marshall,Steven A. Narod,Gilbert M. Lenoir,Henry T. Lynch,Jean Feunteun,Peter Devilee,Cees J. Cornelisse,Fred H. Menko,Peter A. Daly,Wilma Ormiston,Ross McManus,Carole Pye,Cathryn M. Lewis,Lisa A. Cannon-Albright,Julian Peto,Bruce A.J. Ponder,Mark H. Skolnick,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +30 more
TL;DR: This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13, which preliminary evidence suggests suggests confers a high risk of breast cancer but does not confer a substantially elevated risk of ovarian cancer.
Journal ArticleDOI
Risks of cancer in BRCA1-mutation carriers
TL;DR: In this paper, the risks of breast and ovarian cancer from the occurrence of second cancers in individuals with breast cancer, and examined the risk of other cancers in BRCA1 carriers.
Journal Article
Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.
TL;DR: Data from families with evidence of linkage to BRCA1 is used to estimate the age-specific risks of breast and ovarian cancer in BRCa1-mutation carriers and to examine the variation in risk between and within families.
Journal Article
Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.
TL;DR: The results suggest that a gene(s) on chromosome 17q accounts for the majority of families in which both early-onset breast cancer and ovarian cancer occur but that other genes predisposing to breast cancer exist.