Author
D. James Morré
Other affiliations: University of Toulouse, Marquette University, Centre national de la recherche scientifique ...read more
Bio: D. James Morré is an academic researcher from Purdue University. The author has contributed to research in topics: Golgi apparatus & Membrane. The author has an hindex of 50, co-authored 290 publications receiving 8953 citations. Previous affiliations of D. James Morré include University of Toulouse & Marquette University.
Papers published on a yearly basis
Papers
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TL;DR: This review covers recent findings on the medicinal properties and noncancer health benefits of both green and black tea.
Abstract: Tea, in the form of green or black tea, is one of the most widely consumed beverages in the world. Extracts of tea leaves also are sold as dietary supplements. However, with the increasing interest in the health properties of tea and a significant rise in scientific investigation, this review covers recent findings on the medicinal properties and noncancer health benefits of both green and black tea. In Part II, a review of anticancer properties of green tea extracts is presented. Green tea contains a unique set of catechins that possess biological activity in antioxidant, anti-angiogenesis, and antiproliferative assays potentially relevant to the prevention and treatment of various forms of cancer. Although there has been much focus on the biological properties of the major tea catechin epigallocatechin gallate (EGCg) and its antitumor properties, tea offers other health benefits; some due to the presence of other important constituents. Characteristics unrelated to the antioxidant properties of green an...
358 citations
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TL;DR: The results obtained allowed us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
271 citations
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TL;DR: An international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms, and results suggest that a broad-spectrums approach should be feasible from a safety standpoint.
228 citations
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01 Jan 1971TL;DR: The Golgi apparatus in its most familiar form is that part of the cell’s endomembrane system consisting of regions of stacked cisternae (dictyosomes) which lack ribosomes, a complex structure with unique functions in compartmentalizing products of synthesis and producing exocytotic vesicles whose membranes are capable of fusing with plasma membrane.
Abstract: The Golgi apparatus in its most familiar form is that part of the cell’s endomembrane system1 consisting of regions of stacked cisternae (dictyosomes) which lack ribosomes. It is a complex structure with unique functions in compartmentalizing products of synthesis, serving as a site of cytomembrane differentiation and producing exocytotic vesicles whose membranes are capable of fusing with plasma membrane. Unlike semiautonomous organelles such as chloroplasts and mitochondria, the function of the Golgi apparatus in secretion depends on functional continuity with other components of the endomembrane system.
227 citations
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TL;DR: Golgi apparatus fractions from rat liver contained all glycosyltransferases which catalyze the in vitro biosynthesis of N-acetylneuraminylgalactosylglucosylceramide, and results show that gangliosides are not synthesized at the surface membrane.
204 citations
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TL;DR: The title of the Nobel Lecture of George Palade (1 August, p. 347) should have been "Intracellular aspects of the process of protein secretion."
Abstract: The title of the Nobel Lecture of George Palade (1 August, p. 347) should have been "Intracellular aspects of the process of protein secretion."
3,129 citations
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2,057 citations
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TL;DR: O Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction.
Abstract: The first suggestion that physical exercise results in free radical-mediated damage to tissues appeared in 1978, and the past three decades have resulted in a large growth of knowledge regarding exercise and oxidative stress. Although the sources of oxidant production during exercise continue to be debated, it is now well established that both resting and contracting skeletal muscles produce reactive oxygen species and reactive nitrogen species. Importantly, intense and prolonged exercise can result in oxidative damage to both proteins and lipids in the contracting myocytes. Furthermore, oxidants can modulate a number of cell signaling pathways and regulate the expression of multiple genes in eukaryotic cells. This oxidant-mediated change in gene expression involves changes at transcriptional, mRNA stability, and signal transduction levels. Furthermore, numerous products associated with oxidant-modulated genes have been identified and include antioxidant enzymes, stress proteins, DNA repair proteins, and mitochondrial electron transport proteins. Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species promote contractile dysfunction resulting in muscle weakness and fatigue. Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction.
2,017 citations
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01 Jun 1996TL;DR: The review addresses the above from molecular to whole-plant levels and considers emerging models for sensing and transducing carbohydrate signals to responsive genes.
Abstract: Plant gene responses to changing carbohydrate status can vary markedly Some genes are induced, some are repressed, and others are minimally affected As in microorganisms, sugar-sensitive plant genes are part of an ancient system of cellular adjustment to critical nutrient availability However, in multicellular plants, sugar-regulated expression also provides a mechanism for control of resource distribution among tissues and organs Carbohydrate depletion upregulates genes for photosynthesis, remobilization, and export, while decreasing mRNAs for storage and utilization Abundant sugar levels exert opposite effects through a combination of gene repression and induction Long-term changes in metabolic activity, resource partitioning, and plant form result Sensitivity of carbohydrate-responsive gene expression to environmental and developmental signals further enhances its potential to aid acclimation The review addresses the above from molecular to whole-plant levels and considers emerging models for sensing and transducing carbohydrate signals to responsive genes
1,727 citations
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TL;DR: The majority of neutral glycolipids present in plasma membranes are cryptic, and further extensive studies of the organization of glycolIPid in other eukaryotic cell membranes are necessary.
Abstract: The idea that glycosphingolipids (or, briefly, glycolipids) are ubiquitous components of plasma membrane and display cell type-specific patterns perhaps stemmed from the classical studies on glycolipids of erythrocyte membranes.(1,2) Subsequently, plasma membranes of various animal cells were successfully isolated and analyzed; all were characterized by their much higher content of glycolipid than was found in intracellular membranes.(3–8) It is generally assumed that glycolipids are present at the outer leaflet of the plasma membrane bilayer, although this assumption is based only on experiments with surface-labeling by galactose oxidase-NaB[3H]4 of intact and lysed erythrocyte membranes and inside-out vesicles.(9,10) Obviously, further extensive studies of the organization of glycolipid in other eukaryotic cell membranes are necessary. Interestingly, the majority of neutral glycolipids present in plasma membranes are cryptic (see Section 4.2.1).
1,637 citations