D. Lefort

Bio: D. Lefort is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Alcohol oxidation & Formaldehyde. The author has an hindex of 2, co-authored 2 publications receiving 20 citations.

On the free-radical reaction of primary alcohols with formaldehyde

Abstract: The reaction of primary alcohols with formalin or paraformaldehyde initiated by t-butyl peroxide in a glass apparatus under atmospheric pressure leads to the formation of alkane-1,2-diols.

Free-radical addition of alcohols and acids to 10-undecenoic esters, 10-undecen-1-Ol, and 10-undecenyl acetate

Abstract: A method was developed for the synthesis of hydroxy carboxylic acids by the addition of saturated alcohols and acids to 10-undecenoic acid and 10-undecen-1-ol.

Simulation of nonbranched chain processes for producing 1,2-alkanediols in alcohol-formaldehyde systems

Abstract: A mechanism of the initiated nonbranched chain process of forming 1,2-alkanediols and carbonyl compounds in alcohol-formaldehyde systems is developed. The quasi-steady-state treatment is used to obtain kinetic equations that can describe the nonmonotonic (with a maximum) dependences of the formation rates of the products on the concentration of free (desolvated) dissolved formaldehyde.

Fatty acids and their use in conjugation to biomolecules

Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Competition Kinetics of the Non-branched-Chain Processes of Free Radical Addition to the C=C, C=O, and O=O Bonds of Molecules 1

Abstract: The aim of our study was the conclusion of the simple kinetic equations to describe ab initio the initiated non-branched-chain processes of saturated free radical addition to C=C, C=O, and O=O bonds of molecules in the binary systems of saturated and unsaturated components. In the processes of this kind the formation rate of the molecular addition products (1:1 adducts) as a function of concentration of the unsaturated component has a maximum. Five reaction schemes are suggested for addition processes of free radicals to the multiple bonds of molecules. The schemes include reactions competing with chain propagation through a reactive free radical. The chain evolution stage in these schemes involves three or four types of free radicals, of which one is relatively low-reactive and inhibits the chain process by shortening of the kinetic chain length. Based on the suggested schemes, nine rate equations containing one to three parameters to be determined directly are set up using quasi-steady-state treatment. These equations provide good fits for the non-monotonic (peaking) dependences of the formation rates of the molecular 1:1 adducts on the concentration of the unsaturated component in liquid homogeneous binary systems consisting of a saturated component (hydrocarbon, alcohol, etc.) and an unsaturated component (olefin, allyl alcohol, formaldehyde, or dioxygen). The unsaturated compound in these systems is both a reactant and an autoinhibitor generating low-reactive free radicals such as СН2=С(СН3)ĊН2, СН2=СНĊНОН, НĊ=O, o-СН3С6Н4СН2

Kinetics of Nonbranched-Chain Processes of the Free-Radical Addition to Molecules of Alkenes, Formaldehyde, and Oxygen with Competing Reactions of Resulting 1:1 Adduct Radicals with Saturated and Unsaturated Components of the Binary Reaction System

Abstract: Five reaction schemes are suggested for the initiated nonbranchedchain addition of free radicals to the multiple bonds of the unsaturated compounds. The proposed schemes include the reaction competing with chain propagation reactions through a reactive free radical. The chain evolution stage in these schemes involves three or four types of free radicals. One of them is relatively low-reactive and inhibits the chain process by shortening of the kinetic chain length. Based on the suggested schemes, nine rate equations (containing one to three parameters to be determined directly) are deduced using quasi-steady-state treatment. These equations provide good fits for the nonmonotonic (peaking) dependences of the formation rates of the molecular products (1:1 adducts) on the concentration of the unsaturated component in binary systems consisting of a saturated component (hydrocarbon, alcohol, etc.) and an unsaturated component (alkene, allyl alcohol, formaldehyde, or dioxygen). The unsaturated compound in these systems is both a reactant and an autoinhibitor generating low-reactive free radicals. A similar kinetic description is applicable to the nonbranched-chain process of the free-radical hydrogen oxidation, in which the oxygen with the increase of its concentration begins to act as an oxidation autoingibitor (or an antioxidant). The energetics of the key radicalmolecule reactions is considered.