D
D. Michiel Pegtel
Researcher at VU University Amsterdam
Publications - 69
Citations - 8721
D. Michiel Pegtel is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Microvesicles & Medicine. The author has an hindex of 30, co-authored 51 publications receiving 6708 citations. Previous affiliations of D. Michiel Pegtel include VU University Medical Center & Netherlands Cancer Institute.
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Journal ArticleDOI
Functional delivery of viral miRNAs via exosomes
D. Michiel Pegtel,Katherine Cosmopoulos,David A. Thorley-Lawson,Monique A. J. van Eijndhoven,Erik S. Hopmans,Jelle J. Lindenberg,Tanja D. de Gruijl,Thomas Wurdinger,Jaap M. Middeldorp +8 more
TL;DR: These findings are consistent with miRNA-mediated gene silencing as a potential mechanism of intercellular communication between cells of the immune system that may be exploited by the persistent human γ-herpesvirus EBV.
Journal ArticleDOI
Methodological Guidelines to Study Extracellular Vesicles.
Frank A. W. Coumans,Alain Brisson,Edit I. Buzás,Françoise Dignat-George,Esther E.E. Drees,Samir El-Andaloussi,Samir El-Andaloussi,Costanza Emanueli,Costanza Emanueli,Aleksandra Gasecka,Aleksandra Gasecka,An Hendrix,Andrew F. Hill,Romaric Lacroix,Yi Lee,Ton G. van Leeuwen,Nigel Mackman,Imre Mäger,Imre Mäger,John P. Nolan,Edwin van der Pol,D. Michiel Pegtel,Susmita Sahoo,Pia Siljander,Guus Sturk,Olivier De Wever,Rienk Nieuwland +26 more
TL;DR: This review provides an expert-based update of recent advances in the methods to study EVs and summarizes currently accepted considerations and recommendations from sample collection to isolation, detection, and characterization of EVs.
Journal ArticleDOI
Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species.
Serena Rubina Baglìo,Koos Rooijers,Danijela Koppers-Lalic,Frederik J. Verweij,M Pérez Lanzón,Nicoletta Zini,B.A. Naaijkens,Francesca Perut,Hans W.M. Niessen,Nicola Baldini,D. Michiel Pegtel +10 more
TL;DR: It is demonstrated that primary MSCs release small RNAs via exosomes, which are increasingly implicated in intercellular communications, and may help to understand how M SCs impact neighboring or distant cells with possible consequences for their therapeutic usage.
Journal ArticleDOI
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper
Bogdan Mateescu,Emma J. K. Kowal,Bas W.M. van Balkom,Sabine Bartel,Suvendra N. Bhattacharyya,Edit I. Buzás,Amy H. Buck,Paola de Candia,Franklin Wang Ngai Chow,Saumya Das,Tom A. P. Driedonks,Lola Fernández-Messina,Franziska Haderk,Andrew F. Hill,Jennifer Jones,Kendall Van Keuren-Jensen,Charles P. Lai,Cecilia Lässer,Italia Di Liegro,Taral R. Lunavat,Magdalena J. Lorenowicz,Sybren L. N. Maas,Imre Mäger,María Mittelbrunn,Stefan Momma,Kamalika Mukherjee,Muhammad Nawaz,D. Michiel Pegtel,Michael W. Pfaffl,Raymond M. Schiffelers,Hidetoshi Tahara,Clotilde Théry,Juan Pablo Tosar,Marca H. M. Wauben,Kenneth W. Witwer,Esther N. M. Nolte-‘t Hoen +35 more
TL;DR: This position paper was written by the participants of the workshop to give an overview of the current state of knowledge in the field and to clarify that incomplete knowledge – of the nature of EV(-RNA)s and of how to effectively and reliably study them – currently prohibits the implementation of gold standards in EV-RNA research.
Journal ArticleDOI
Biogenesis and function of extracellular vesicles in cancer.
TL;DR: This review highlights key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells and discusses how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.