Author
D. Procházková
Bio: D. Procházková is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Genitourinary system & Congenital diaphragmatic hernia. The author has an hindex of 1, co-authored 1 publications receiving 981 citations.
Papers
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TL;DR: The aim of this review is to discuss both the antioxidant and prooxidant effects of flavonoids.
1,152 citations
TL;DR: Cardiacurogenital syndrome [MIM # 618280] is a very rare very rare syndrome associated with pathogenic variants in the myelin regulatory factor (MYRF) gene that leads to loss of protein function as discussed by the authors .
Abstract: Cardiac‐urogenital syndrome [MIM # 618280] is a newly described very rare syndrome associated with pathogenic variants in the myelin regulatory factor (MYRF) gene that leads to loss of protein function. MYRF is a transcription factor previously associated only with the control of myelin‐related gene expression. However, it is also highly expressed in other tissues and associated with various organ anomalies. The clinical picture is primarily dominated by complex congenital cardiac developmental defects, pulmonary hypoplasia, congenital diaphragmatic hernia, and urogenital malformations.
1 citations
TL;DR: The DYRK 1A-related intellectual disability syndrome (DYRK1A) as discussed by the authors ) is a type of disability that is characterized by hypertonie, dysmorfie, hypertonies, dysmorphic dysmorphy and hypertonia.
Abstract: Syndrom intelektuĂĄlnĂho postiĹženĂ souvisejĂcĂ s DYRK1A (DYRK1A-related intellectual disability syndrome) je autozomĂĄlnÄ dominantnĂ onemocnÄnĂ charakterizovanĂŠ stĹednĂm aĹž tÄĹžkĂ˝m intelektuĂĄlnĂm postiĹženĂm, zpoĹždÄnĂm vĂ˝voje ĹeÄi, poruchou autistickĂŠho spektra a mikrocefaliĂ. TypickĂŠ jsou kraniofaciĂĄlnĂ dysmorfie, potĂĹže s krmenĂm, malĂ˝ vzrĹŻst, hypertonie, poruchy chĹŻze. V kojeneckĂŠm vÄku bĂ˝vajĂ Äasto febrilnĂ zĂĄchvaty, pozdÄji vĂ˝voj epilepsie. CĂlem naĹĄeho kazuistickĂŠho sdÄlenĂ je prezentace 3letĂŠ pacientky s tĂmto syndromem. U naĹĄĂ pacientky bylo vzhledem k vyÄerpanĂ˝m diagnostickĂ˝m moĹžnostem a neobjasnÄnĂŠ pĹĂÄinÄ intelektuĂĄlnĂho postiĹženĂ provedeno celoexomovĂŠ sekvenovĂĄnĂ (WES). PomocĂ tĂŠto metody jsme nalezli heterozygotnĂ patogennĂ variantu p.R205* v genu DYRK1A, coĹž umoĹžnilo rychlĂŠ stanovenĂ kauzĂĄlnĂ diagnĂłzy. Lze tedy ĹĂct, Ĺže WES pĹedstavuje ĂşÄinnĂ˝ diagnostickĂ˝ nĂĄstroj pro detekci mutacĂ, kterĂŠ jsou pĹĂÄinou rĹŻznĂ˝ch syndromĹŻ spojenĂ˝ch s intelektuĂĄlnĂm postiĹženĂm.
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TL;DR: In this review, the most recent findings in the oxidative stress field are described, highlighting both its bad and good sides for human health.
Abstract: Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products. ROS can play, and in fact they do it, several physiological roles (i.e., cell signaling), and they are normally generated as by-products of oxygen metabolism; despite this, environmental stressors (i.e., UV, ionizing radiations, pollutants, and heavy metals) and xenobiotics (i.e., antiblastic drugs) contribute to greatly increase ROS production, therefore causing the imbalance that leads to cell and tissue damage (oxidative stress). Several antioxidants have been exploited in recent years for their actual or supposed beneficial effect against oxidative stress, such as vitamin E, flavonoids, and polyphenols. While we tend to describe oxidative stress just as harmful for human body, it is true as well that it is exploited as a therapeutic approach to treat clinical conditions such as cancer, with a certain degree of clinical success. In this review, we will describe the most recent findings in the oxidative stress field, highlighting both its bad and good sides for human health.
1,810 citations
TL;DR: The present review tries to shed some light on research on antioxidants (natural and synthetic) and prooxidants, showing the potential benefits and adverse effects of these opposing events, as well as their mechanisms of action and detection methodologies.
1,286 citations
TL;DR: A review on the chemistry and biochemistry of dietary polyphenols, their antioxidant and anti-inflammatory activities, and the underlying molecular mechanisms of their involvement in inflammation mediated metabolic diseases are also discussed in this article.
Abstract: Phenolic compounds including phenolic acids, flavonoids and proanthocyanidins are widely distributed in plants as a protective mechanism against biotic and abiotic stresses. Fruits, vegetables, grains, spices and herbs are the richest source of dietary polyphenols. High intake of these foods has been linked to lowered risk of most common degenerative and chronic diseases that are known to be caused by oxidative stress. This review intends to summarize briefly recent progress on the chemistry and biochemistry of dietary polyphenols, their antioxidant and anti-inflammatory activities, and the underlying molecular mechanisms of their involvement in inflammation mediated metabolic diseases are also discussed. Perspectives for future research are also briefly discussed.
936 citations
TL;DR: Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits, it is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.
Abstract: Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables. The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, metabolic disorders, and certain types of cancer. These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins oxidation and platelet aggregation, and acting as vasodilators in blood vessels. Free radicals are constantly generated resulting in extensive damage to tissues leading to various disease conditions such as cancer, Alzheimer's, renal diseases, cardiac abnormalities, etc., Medicinal plants with antioxidant properties play a vital functions in exhibiting beneficial effects and employed as an alternative source of medicine to mitigate the disease associated with oxidative stress. Flavonoids have existed over one billion years and possess wide spectrum of biological activities that might be able to influence processes which are dysregulated in a disease. Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits. It is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.
824 citations
Kerman Medical University1, Manipal University2, University of Cagliari3, University of Salento4, University of Belgrade5, University of Bamenda6, Canadian Real Estate Association7, Central University, India8, Holy Spirit University of Kaslik9, University of Porto10, University of Concepción11, University of Medicine and Pharmacy of Craiova12, University of Alabama in Huntsville13, Hospital Authority14, Shahid Beheshti University of Medical Sciences and Health Services15
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
Abstract: Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.
619 citations