D
D Thirumal Kumar
Researcher at VIT University
Publications - 50
Citations - 882
D Thirumal Kumar is an academic researcher from VIT University. The author has contributed to research in topics: Mutant & Mutation. The author has an hindex of 16, co-authored 41 publications receiving 638 citations.
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Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer.
TL;DR: This study identified the most relevant biological networks involving DEGs that were mainly enriched in the cell cycle (in metaphase checkpoints) and revealed the role of APC in cell cycle regulation pathways.
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Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients - A Bioinformatics Approach.
S. Udhaya Kumar,D Thirumal Kumar,Ramamoorthy Siva,C. George Priya Doss,Salma Younes,Nadin Younes,Mariem Sidenna,Hatem Zayed +7 more
TL;DR: Four genes (EGR1, CD38, CAV1, and AKT1) were identified to be strongly associated with SLE and might serve as potential biomarkers in early diagnosis and as therapeutic targets for SLE.
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Influence of V54M mutation in giant muscle protein titin: a computational screening and molecular dynamics approach
D Thirumal Kumar,C. George Priya Doss,P. Sneha,Iftikhar Aslam Tayubi,Ramamoorthy Siva,Chiranjib Chakraborty,R. Magesh +6 more
TL;DR: The deleterious mutant V54M was mapped, modeled the mutant protein complex, and deciphered the impact of mutation on binding with its partner telethonin in the titin crystal structure of PDB ID: 1YA5 with the aid of docking analysis to understand the mechanistic action of V 54M mutation in altering the protein structure, dynamics, and stability.
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Unraveling the inhibition mechanism of cyanidin-3-sophoroside on polyphenol oxidase and its effect on enzymatic browning of apples.
Hridya Hemachandran,Amrita Anantharaman,Sankari Mohan,Gopalakrishnan Mohan,D Thirumal Kumar,Diksha Dey,D. Kumar,Priyanka Dey,Amrita Choudhury,C. George Priya Doss,Siva Ramamoorthy +10 more
TL;DR: C cyanidin-3-sophoroside from Garcinia mangostana rind appears to be a promising anti-browning agent to control enzymatic browning.
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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach.
TL;DR: The HNF1A protein was retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism and the MD approach is an important tool for elucidating the impact and affinity of mutations in DNA-protein interactions and understanding their function.