D
da Silva Lg
Researcher at University of Mainz
Publications - 1
Citations - 37
da Silva Lg is an academic researcher from University of Mainz. The author has contributed to research in topics: Protein aggregation & Casein kinase 1. The author has an hindex of 1, co-authored 1 publications receiving 3 citations.
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Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation
da Silva Lg,Simonetti F,Simonetti F,Hutten S,Riemenschneider H,Sternburg El,Lisa M. Pietrek,Jakob Gebel,Dötsch,Dieter Edbauer,Gerhard Hummer,Gerhard Hummer,Lukas S. Stelzl,Dorothee Dormann,Dorothee Dormann +14 more
TL;DR: This article showed that TDP-43 hyperphosphorylation by Casein kinase 1δ or C-terminal phosphomimetic mutations surprisingly reduced phase separation and aggregation, and rendered the protein more liquid-like and dynamic.