Author
Dadong Wang
Other affiliations: Jilin Normal University, University of Wollongong, Northeastern University (China) ...read more
Bio: Dadong Wang is an academic researcher from Commonwealth Scientific and Industrial Research Organisation. The author has contributed to research in topics: Toolbox & Feature extraction. The author has an hindex of 18, co-authored 107 publications receiving 2803 citations. Previous affiliations of Dadong Wang include Jilin Normal University & University of Wollongong.
Papers published on a yearly basis
Papers
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TL;DR: This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds.
1,287 citations
TL;DR: It is demonstrated that chitosan solutions can be neutralised up to physiological pH (∼7.2) using β-glycerol phosphate without creating immediate gel-like precipitation and furthermore that subsequent heating of these solutions induces hydrogel formation.
483 citations
TL;DR: In this article, a multiscale morphology analysis is applied to one-dimensional signal by defining both the length and height scales of structuring elements (SEs) and a local-peak value based adaptive algorithm is also introduced.
170 citations
TL;DR: It is identified that apigenin has potent anti-inflammatory properties with the ability to protect neurites and cell viability by promoting a global down-regulation of cytokine and nitric oxide release in inflammatory cells and is able to protect iPSC-derived AD neurons via multiple means.
Abstract: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however a comprehensive assessment has not been performed in a human model of AD. Here we have used a human induced pluripotent stem cell (iPSC) model of familial and sporadic AD, in addition to healthy controls, to assess the neuroprotective activity of apigenin. The iPSC-derived AD neurons demonstrated a hyper-excitable calcium signalling phenotype, elevated levels of nitrite, increased cytotoxicity and apoptosis, reduced neurite length and increased susceptibility to inflammatory stress challenge from activated murine microglia, in comparison to control neurons. We identified that apigenin has potent anti-inflammatory properties with the ability to protect neurites and cell viability by promoting a global down-regulation of cytokine and nitric oxide (NO) release in inflammatory cells. In addition, we show that apigenin is able to protect iPSC-derived AD neurons via multiple means by reducing the frequency of spontaneous Ca(2+) signals and significantly reducing caspase-3/7 mediated apoptosis. These data demonstrate the broad neuroprotective action of apigenin against AD pathogenesis in a human disease model.
147 citations
TL;DR: Fast, sensitive, and reliable algorithms for the purpose of detecting and analyzing neurites in cell cultures are developed and integrated in software, suitable for the research environment, called HCA‐Vision, which delivered considerable speed benefits and reliable traces.
Abstract: Manual neuron tracing is a very labor-intensive task. In the drug screening context, the sheer number of images to process means that this approach is unrealistic. Moreover, the lack of reproducibility, objectivity, and auditing capability of manual tracing is limiting even in the context of smaller studies. We have developed fast, sensitive, and reliable algorithms for the purpose of detecting and analyzing neurites in cell cultures, and we have integrated them in software called HCA-Vision, suitable for the research environment. We validate the software on images of cortical neurons by comparing results obtained using HCA-Vision with those obtained using an established semi-automated tracing solution (NeuronJ). The effect of the Sez-6 deletion was characterized in detail. Sez-6 null neurons exhibited a significant increase in neurite branching, although the neurite field area was unchanged due to a reduction in mean branch length. HCAVision delivered considerable speed benefits and reliable traces. ' 2007 International Society for Analytical Cytology
75 citations
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TL;DR: Chitin is the second most important natural polymer in the world as mentioned in this paper, and the main sources of chitin are two marine crustaceans, shrimp and crabs, which are used for food, cosmetics, biomedical and pharmaceutical applications.
6,365 citations
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01 Feb 2009
TL;DR: This Secret History documentary follows experts as they pick through the evidence and reveal why the plague killed on such a scale, and what might be coming next.
Abstract: Secret History: Return of the Black Death Channel 4, 7-8pm In 1348 the Black Death swept through London, killing people within days of the appearance of their first symptoms. Exactly how many died, and why, has long been a mystery. This Secret History documentary follows experts as they pick through the evidence and reveal why the plague killed on such a scale. And they ask, what might be coming next?
5,234 citations
TL;DR: Hydrogels are an appealing scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner.
4,573 citations
4,511 citations
Journal Article•
3,940 citations