D
Daichi Shigemizu
Researcher at Tokyo Medical and Dental University
Publications - 54
Citations - 1811
Daichi Shigemizu is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 18, co-authored 49 publications receiving 1329 citations. Previous affiliations of Daichi Shigemizu include Kyoto University.
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PathPred: an enzyme-catalyzed metabolic pathway prediction server
Yuki Moriya,Daichi Shigemizu,Masahiro Hattori,Toshiaki Tokimatsu,Masaaki Kotera,Susumu Goto,Minoru Kanehisa +6 more
TL;DR: This server presents PathPred, a web-based server to predict plausible pathways of muti-step reactions starting from a query compound, based on the local RDM pattern match and the global chemical structure alignment against the reactant pair library.
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DeepInsight: a methodology to transform a non - image data to an image for convolution neural network architecture
Alokanand Sharma,Edwin Vans,Edwin Vans,Daichi Shigemizu,Keith A. Boroevich,Tatsuhiko Tsunoda +5 more
TL;DR: This work proposes, DeepInsight, which converts non-image samples into a well-organized image-form, and enables feature extraction through the application of CNN for non- image samples to seize imperative information and shown promising results.
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Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity
Akihiro Fujimoto,Mayuko Furuta,Yuichi Shiraishi,Kunihito Gotoh,Yoshiiku Kawakami,Koji Arihiro,Toru Nakamura,Masaki Ueno,Shunichi Ariizumi,Ha Hai Nguyen,Daichi Shigemizu,Tetsuo Abe,Keith A. Boroevich,Kaoru Nakano,Aya Sasaki,Rina Kitada,Kazihiro Maejima,Yujiro Yamamoto,Hiroko Tanaka,Tetsuo Shibuya,Tatsuhiro Shibata,Hidenori Ojima,Kazuaki Shimada,Shinya Hayami,Yoshinobu Shigekawa,Hiroshi Aikata,Hideki Ohdan,Shigeru Marubashi,Terumasa Yamada,Michiaki Kubo,Satoshi Hirano,Osamu Ishikawa,Masakazu Yamamoto,Hiroki Yamaue,Kazuaki Chayama,Satoru Miyano,Tatsuhiko Tsunoda,Hidewaki Nakagawa +37 more
TL;DR: The genome-wide substitution patterns of LCBs developed in chronic hepatitis livers overlapped with those of 60 HCCs, whereas those of hepatitis-negative LCBs diverged, revealing the strong impact of chronic hepatitis on the mutational landscape in liver cancer and the genetic diversity among LCBs.
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Novel calmodulin mutations associated with congenital arrhythmia susceptibility.
Naomasa Makita,Nobue Yagihara,Lia Crotti,Christopher N. Johnson,Britt M. Beckmann,Michelle S. Roh,Daichi Shigemizu,Peter Lichtner,Taisuke Ishikawa,Takeshi Aiba,Tessa Homfray,Elijah R. Behr,Didier Klug,Isabelle Denjoy,Elisa Mastantuono,Daniel Theisen,Tatsuhiko Tsunoda,Wataru Satake,Tatsushi Toda,Hidewaki Nakagawa,Yukiomi Tsuji,Takeshi Tsuchiya,Hirokazu Yamamoto,Yoshihiro Miyamoto,Naoto Endo,Akinori Kimura,Kouichi Ozaki,Hideki Motomura,Kenji Suda,Toshihiro Tanaka,Peter J. Schwartz,Thomas Meitinger,Stefan Kääb,Pascale Guicheney,Wataru Shimizu,Zahurul A. Bhuiyan,Hiroshi Watanabe,Walter J. Chazin,Alfred L. George +38 more
TL;DR: CALM2 mutations can be associated with LQTS and with overlapping features of LQ TS and CPVT, and caused reduced Ca2+-binding affinity.
Journal ArticleDOI
High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway
Kosuke Yoshihara,Tatsuhiko Tsunoda,Daichi Shigemizu,Hiroyuki Fujiwara,Masayuki Hatae,Hisaya Fujiwara,Hideaki Masuzaki,Hidetaka Katabuchi,Yosuke Kawakami,Aikou Okamoto,Takayoshi Nogawa,Noriomi Matsumura,Yasuhiro Udagawa,Tsuyoshi Saito,Hiroaki Itamochi,Masashi Takano,Etsuko Miyagi,Tamotsu Sudo,Kimio Ushijima,Haruko Iwase,Hiroyuki Seki,Yasuhisa Terao,Takayuki Enomoto,Mikio Mikami,Kohei Akazawa,Hitoshi Tsuda,Takuya Moriya,Atsushi Tajima,Ituro Inoue,Kenichi Tanaka +29 more
TL;DR: Through gene ontology and pathway analyses, a significant reduction in expression of immune-response–related genes, especially on the antigen presentation pathway, in high-risk ovarian cancer patients is identified.