Daiichiro Nakahara

TL;DR: Findings indicate that self-stimulation of the MFB in rats induces increases in both DA and serotonin activities in the NAC, which may be involved in mediating self- Stimulating the medial forebrain bundle.

TL;DR: N‐Methylation of (R)‐1‐methyl‐6,7‐dihydroxy‐1,2,3,4‐tetrahydroisoquinoline [(R]‐salsolinol] derived from dopamine was proved by in vivo microdialysis study in the rat brain to be an essential step for these alkaloids to increase their toxicity.

TL;DR: The results indicate that self-stimulation of the MFB preferentially activates the mesocorticolimbic DA systems, thereby bilateral increases in the release of DA and its metabolism being produced in their terminal regions, the MFC and NAC.

TL;DR: The results suggest that L-DOPA and 5-HTP, the precursor amino acids for catecholamines and indoleamines, could affect mutually each other neuronal activity through the inhibition of their rate-limiting enzymes.

TL;DR: By postmortem analysis of the striatal tissue MPP+ was proved to cause the inhibition of monoamine oxidase (MAO), especially MAO-B and the release of DA.