D
Daisuke Ibi
Researcher at Meijo University
Publications - 60
Citations - 2968
Daisuke Ibi is an academic researcher from Meijo University. The author has contributed to research in topics: Schizophrenia & Hippocampal formation. The author has an hindex of 26, co-authored 53 publications receiving 2587 citations. Previous affiliations of Daisuke Ibi include Icahn School of Medicine at Mount Sinai & Nihon University.
Papers
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Journal ArticleDOI
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction
Kazuhiro Takuma,Fang Fang,Wensheng Zhang,Wensheng Zhang,Shiqiang Yan,Shiqiang Yan,Emiko Fukuzaki,Heng Du,Alexander A. Sosunov,Guy M. McKhann,Yoko Funatsu,Noritaka Nakamichi,Taku Nagai,Taku Nagai,Hiroyuki Mizoguchi,Hiroyuki Mizoguchi,Daisuke Ibi,Daisuke Ibi,Osamu Hori,Satoshi Ogawa,David M. Stern,Kiyofumi Yamada,Kiyofumi Yamada,Shirley ShiDu Yan +23 more
TL;DR: It is demonstrated that receptor for advanced glycation end products (RAGE) contributes to transport of Aβ from the cell surface to the intracellular space, thereby enhancing Aβ cytotoxicity.
Journal ArticleDOI
Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice
Daisuke Ibi,Kazuhiro Takuma,Hiroyuki Koike,Hiroyuki Mizoguchi,Katsuki Tsuritani,Katsuki Tsuritani,Yusuke Kuwahara,Hiroyuki Kamei,Taku Nagai,Yukio Yoneda,Toshitaka Nabeshima,Kiyofumi Yamada,Kiyofumi Yamada +12 more
TL;DR: It is suggested that communication in juvenile is important in the survival and differentiation of newly divided cells, which may be associated with memory and aggression, and the possibility that the reduced expression of Nurr1 and/or Npas4 may contribute to the impairment of neurogenesis and memory and aggressive behaviour induced by SI is raised.
Journal ArticleDOI
Behavioral abnormality and pharmacologic response in social isolation-reared mice
Hiroyuki Koike,Daisuke Ibi,Hiroyuki Mizoguchi,Taku Nagai,Atsumi Nitta,Kazuhiro Takuma,Toshitaka Nabeshima,Yukio Yoneda,Kiyofumi Yamada +8 more
TL;DR: SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.
Journal ArticleDOI
Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex.
Taku Nagai,Kazuhiro Takuma,Hiroyuki Kamei,Yukio Ito,Noritaka Nakamichi,Daisuke Ibi,Yutaka Nakanishi,Masaaki Murai,Hiroyuki Mizoguchi,Toshitaka Nabeshima,Kiyofumi Yamada +10 more
TL;DR: The results suggest that the activation of ERK1/2 following the stimulation of dopamine D1 receptors is necessary for the protein synthesis-dependent long-term retention of recognition memory in the PFC.
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Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus
Hiroyuki Mizoguchi,Junya Nakade,Masaki Tachibana,Daisuke Ibi,Daisuke Ibi,Eiichi Someya,Hiroyuki Koike,Hiroyuki Kamei,Toshitaka Nabeshima,Shigeyoshi Itohara,Kazuhiro Takuma,Makoto Sawada,Jun Sato,Kiyofumi Yamada,Kiyofumi Yamada +14 more
TL;DR: MMP-9 is involved in the progression of behavioral phenotypes in kindled mice because of conversion of pro-BDNF to mature BDNF in the hippocampus, which is accompanied by decreased hippocampal levels of mature brain-derived neurotrophic factor.