D
Daisuke Yamasaki
Researcher at Osaka University
Publications - 13
Citations - 699
Daisuke Yamasaki is an academic researcher from Osaka University. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Transcription factor. The author has an hindex of 12, co-authored 13 publications receiving 642 citations.
Papers
More filters
Journal ArticleDOI
The Role of PPARs in Cancer.
TL;DR: The function of PPARs in tumor growth is reviewed and it is shown that these receptors are molecular targets for the development of drugs treating metabolic syndrome and cancer cell growth.
Journal ArticleDOI
Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms
Keisuke Tachibana,Yumi Kobayashi,Toshiya Tanaka,Masayuki Tagami,Akira Sugiyama,Tatsuya Katayama,Chihiro Ueda,Daisuke Yamasaki,Kenji Ishimoto,Mikako Sumitomo,Yasutoshi Uchiyama,Takahide Kohro,Juro Sakai,Takao Hamakubo,Tatsuhiko Kodama,Takefumi Doi +15 more
TL;DR: It was found that the expression of each PPAR subtype was tightly controlled by the concentration of doxycycline in these established cell lines and suggested that these cell lines are important tools used to identify the human PPARs-responsive genes.
Journal ArticleDOI
Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.
Daisuke Yamasaki,Natsuko Kawabe,Hitomi Nakamura,Keisuke Tachibana,Kenji Ishimoto,Toshiya Tanaka,Hiroyuki Aburatani,Juro Sakai,Takao Hamakubo,Tatsuhiko Kodama,Takefumi Doi +10 more
TL;DR: The results suggest that fenofibrate suppresses Huh7 cell growth through a PPARα independent mechanism, and that CTMP is one of the key players for this antiproliferative property of fen ofibrate in Huh7 cells.
Journal ArticleDOI
Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
Kenji Ishimoto,Hiroki Nakamura,Keisuke Tachibana,Daisuke Yamasaki,Akemi Ota,Ken-ichi Hirano,Toshiya Tanaka,Takao Hamakubo,Juro Sakai,Tatsuhiko Kodama,Takefumi Doi +10 more
TL;DR: It is inferred that sterol-mediated regulation of lipin 1 gene transcription modulates triglyceride accumulation, which involves changes in the activity of phosphatidate phosphatase.
Journal ArticleDOI
Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha
Kenji Ishimoto,Keisuke Tachibana,Mikako Sumitomo,Shiho Omote,Ikuko Hanano,Daisuke Yamasaki,Yuichiro Watanabe,Toshiya Tanaka,Takao Hamakubo,Juro Sakai,Tatsuhiko Kodama,Takefumi Doi +11 more
TL;DR: It is demonstrated that LXRα also regulates the low‐density lipoprotein receptor (LDLR) gene, which mediates the endocytic uptake of LDL cholesterol in the liver.