Daizong Lin

TL;DR: The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route and work that may provide a basis for development of anticoronaviral drugs.

TL;DR: Optimization of the P2 substituent of the α-ketoamides proved crucial for achieving near-equipotency against the three virus genera and six crystal structures of protease–inhibitor complexes were determined.

TL;DR: The crystal structure of the unliganded Mpro was determined at 1.75 Å resolution and used to guide optimization of a series of alpha-ketoamide inhibitors, which will form the basis for further development of these compounds to antiviral drugs.

TL;DR: Structural-based design of peptidomimetic α-ketoamides as inhibitors of main and 3C proteases proved crucial for achieving near-equipotency against the three virus genera.

TL;DR: In this paper , a series of styrene oxazolone dyes (SODs) with simple synthetic methods were designed and synthesized, which showed NIR emissions (>650 nanometers) with long Stokes shift (ranged from 136 to 198 nanometers), and small molecular weight (<450 daltons).