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Dale E. Wurster

Bio: Dale E. Wurster is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Dissolution & Adsorption. The author has an hindex of 13, co-authored 26 publications receiving 654 citations.

Papers
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TL;DR: A new method of rapidly coating drug particles of widely varying size and shape is presented, in this process, the drug particles are coated and dried while suspended in an upwardly moving current of air.
Abstract: A new method of rapidly coating drug particles of widely varying size and shape is presented. In this process, the drug particles are coated and dried while suspended in an upwardly moving current of air. Solutions and suspensions of coating materials in both water and volatile organic solvents are employed. The drying of the coated particles is accomplished at either room or elevated temperatures, depending on the solvent used. Some fundamentals and an introduction to practical applications of the process are given.

120 citations

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TL;DR: Experimental data indicated that moisture conditioning of the skin surface accelerated the absorption rate of three salicylate esters, the greatest effect being observed with the ester having the lowest oil/water distribution coefficient.

108 citations

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TL;DR: It was found that dissolution could be described by consecutive processes involving a reaction at the interface and transport away from the interface, and the data suggested that these processes pose a double barrier to dissolution under the experimental conditions.

90 citations

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TL;DR: It was found that the rates of dissolution in varying concentrations of sodium chloride in neutral solutions can be largely explained by the salting out effects of the electrolyte.
Abstract: A theory is presented which describes the rate of dissolution of solids in basic and buffered media. The formulation is based on the Nernst-Brunner film model assuming a solution diffusion controlled process. Useful expressions are obtained which give relative dissolution rates as functions of the primary variables. Results of calculations predict that for a solid weak acid dissolving in an aqueous basic solution, the rates of dissolution become essentially independent of the strength of the base above certain values. In the region where it is independent of the base strength the rate is a linear function of the product of the base concentration and the base diffusion coefficient. The theoretical conclusions are satisfactorily substantiated by experiments on the rates of dissolution of benzoic acid in basic media of varying strength and diffusivities. The following bases were used as additives: sodium hydroxide, sodium bicarbonate, sodium tetraborate, disodium phosphate, sodium acetate, and ethanolamine. Studies were also carried out with added swamping electrolyte. It was found that the rates of dissolution in varying concentrations of sodium chloride in neutral solutions can be largely explained by the salting out effects of the electrolyte.

55 citations

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TL;DR: A new and rapid method for preparing compressed tablet granulations by the air-suspension technique is discussed and experimental data dealing with material losses and variations in the drug and water content of the prepared granulations are presented.
Abstract: A new and rapid method for preparing compressed tablet granulations by the air-suspension technique is discussed. Experimental data dealing with material losses and variations in the drug and water content of the prepared granulations are presented.

40 citations


Cited by
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Journal ArticleDOI
TL;DR: Against the backdrop of an increasing number of new, poorly orally available drug entities entering development, microparticle delivery systems may be a viable strategy to rescue an otherwise undeliverable substance.

773 citations

Journal ArticleDOI
01 Apr 1967

762 citations

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TL;DR: In this article, the most common methods described in the literature for the production of microencapsulated phase change materials (MEPCMs) are interfacial polymerization, suspension polymerization and spray drying.
Abstract: Microencapsulation of phase change materials (PCMs) is an effective way of enhancing their thermal conductivity and preventing possible interaction with the surrounding and leakage during the melting process, where there is no complete overview of the several methods and techniques for microencapsulation of different kinds of PCMs that leads to microcapsules with different morphology, structure, and thermal properties. In this paper, microencapsulation methods are perused and classified into three categories, i.e. physical, physic-chemical, and chemical methods. It summarizes the techniques used for microencapsulation of PCMs and hence provides a useful tool for the researchers working in this area. Among all the microencapsulation methods, the most common methods described in the literature for the production of microencapsulated phase change materials (MEPCMs) are interfacial polymerization, suspension polymerization, coacervation, emulsion polymerization, and spray drying.

650 citations

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TL;DR: Case studies are presented in which postprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment.

616 citations

Journal ArticleDOI
TL;DR: In this paper, a review of the most important developments in the field of drug dissolution from a historical point of view is presented, which is structured in a chronological order, from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the more recent development in the framework of the Biopharmaceutics Classification System (BCS).

570 citations