Dan L. Sackett

TL;DR: Results identify residues β270 and β364 as important modulators of paclitaxel’s interaction with tubulin as well as acquired mutations in the M40 isotype at nucleotide 810 (T → G; Phe270 → Val) in 1A9PTX10 cells and nucleotide 1092 (G → A; Ala364 → Thr) in1A 9PTX22 cells.

TL;DR: The dye Nile red detects the exposure or formation of new hydrophobic surfaces induced by ligand binding to calmodulin, oligomerization of melittin, or unfolding of ovalbumin during early thermal denaturation.

TL;DR: The unification of taxane, epothilone, and sarcodictyin chemistries in a single pharmacophore provides a framework to study drug-tubulin interactions that should assist in the rational design of agents targeting tubulin.

TL;DR: It is proposed that functional microtubules and the dynein motor protein participate in transport of p53 and facilitate its accumulation in the nucleus after DNA damage.

TL;DR: A previously unknown mechanism of regulation of mitochondrial energetics, governed by VDAC and tubulin at the mitochondria–cytosol interface is suggested, which requires tubulin anionic C-terminal tail (CTT) peptides and may reflect the evolutionary conservation of length and anionic charge in CTT throughout eukaryotes, despite wide changes in the exact sequence.