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Daniel A. Lopez

Bio: Daniel A. Lopez is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Neurocognitive & Medicine. The author has an hindex of 2, co-authored 4 publications receiving 40 citations.

Papers
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Posted ContentDOI
01 Sep 2020-bioRxiv
TL;DR: The ABCD Study aims and design are described, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.
Abstract: The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children9s health in the United States. A cohort of n=11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.

25 citations

Journal ArticleDOI
TL;DR: The authors examined the association between breastfeeding duration and subsequent domain-specific cognitive performance in a diverse sample of 9-10-year-olds enrolled in the Adolescent Brain Cognitive Development (ABCD) Study.
Abstract: Significant immunological, physical and neurological benefits of breastfeeding in infancy are well-established, but to what extent these gains persist into later childhood remain uncertain. This study examines the association between breastfeeding duration and subsequent domain-specific cognitive performance in a diverse sample of 9-10-year-olds enrolled in the Adolescent Brain Cognitive Development (ABCD) Study®. The analyses included 9,116 children that attended baseline with their biological mother and had complete neurocognitive and breastfeeding data. Principal component analysis was conducted on data from an extensive battery of neurocognitive tests using varimax-rotation to extract a three-component model encompassing General Ability, Executive Functioning, and Memory. Propensity score weighting using generalized boosted modeling was applied to balance the distribution of observed covariates for children breastfed for 0, 1-6, 7-12, and more than 12 months. Propensity score-adjusted linear regression models revealed significant association between breastfeeding duration and performance on neurocognitive tests representing General Ability, but no evidence of a strong association with Executive Function or Memory. Benefits on General Ability ranged from a 0.109 (1-6 months) to 0.301 (>12 months) standardized beta coefficient difference compared to those not breastfed. Results indicate clear cognitive benefits of breastfeeding but that these do not generalize to all measured domains, with implications for public health policy as it pertains to nutrition during infancy.

13 citations

Journal ArticleDOI
TL;DR: For instance, this article found that mild traumatic brain injury (mTBI) is associated with psychopathology and structural brain metrics (e.g., volume, area) meaningfully mediate the relation in an adolescent population.

4 citations


Cited by
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Book ChapterDOI
01 Jan 2008

58 citations

Journal ArticleDOI
TL;DR: In this paper, a review of recent findings of typical postnatal macro-and microstructural development of the cerebral cortex from early childhood to young adulthood is presented, integrating imaging studies with cortical gene expression findings to further understand the underlying neurobiology of the developmental changes, bridging the gap between ex vivo histological-and in vivo MRI studies.

45 citations

Journal ArticleDOI
TL;DR: In this article, the authors provide a brief overview of diffusion magnetic resonance imaging (dMRI) methods and how they can be used to study white matter and connectivity and review the extant literature examining the links between dMRI indices and executive functions during development.

19 citations

Journal ArticleDOI
TL;DR: In this article, a longitudinal structural equation model was used to examine the indirect effect of adversity exposure (negative life events) on later psychopathology via changes in cortico-limbic resting-state functional connectivity (rsFC).

16 citations

Journal ArticleDOI
TL;DR: Early adversity influences brain development and emerging behavioral phenotypes relevant for psychiatric disorders as discussed by the authors, which has implications for contextualizing current public health crises and pervasive health inequities, and highlight targets for future research.

15 citations