D
Daniel C. Douek
Researcher at University of Texas Southwestern Medical Center
Publications - 30
Citations - 4153
Daniel C. Douek is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: T cell & CD8. The author has an hindex of 14, co-authored 30 publications receiving 4052 citations. Previous affiliations of Daniel C. Douek include University of Texas at Dallas.
Papers
More filters
Journal ArticleDOI
Changes in thymic function with age and during the treatment of HIV infection
Daniel C. Douek,Richard D. McFarland,Phillip H. Keiser,Earl A. Gage,Janice M. Massey,Barton F. Haynes,Michael A. Polis,Ashley T. Haase,Mark B. Feinberg,John L. Sullivan,Beth D. Jamieson,Jerome A. Zack,Louis J. Picker,Richard A. Koup +13 more
TL;DR: It is found that, although thymic function declines with age, substantial output is maintained into late adulthood and this results indicate that the adult thymus can contribute to immune reconstitution following HAART.
Journal ArticleDOI
Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution
Daniel C. Douek,Robert Vescio,Michael R. Betts,Jason M. Brenchley,Brenna J. Hill,Lan Zhang,James R. Berenson,Robert H. Collins,Richard A. Koup +8 more
TL;DR: Evidence is provided that the adult thymus contributes more substantially to immune reconstitution after haematopoietic stem-cell transplantation than was previously thought, and therefore could be a target for therapeutic intervention.
Journal ArticleDOI
Generation of Functional Thymocytes in the Human Adult
Beth D. Jamieson,Daniel C. Douek,Scott Killian,Lance E. Hultin,Deirdre D. Scripture-Adams,Janis V. Giorgi,Daniel Marelli,Richard A. Koup,Jerome A. Zack +8 more
TL;DR: Examining thymopoiesis in adults up to 56 years of age finds active T cell receptor (TCR) rearrangement, generating a diverse TCR Vbeta repertoire and demonstrating that the adult thymus remains active late in life and contributes functional T cells to the peripheral lymphoid pool.
Journal ArticleDOI
Leukemia Inhibitory Factor, Oncostatin M, IL-6, and Stem Cell Factor mRNA Expression in Human Thymus Increases with Age and Is Associated with Thymic Atrophy
Gregory D. Sempowski,Laura P. Hale,John S. Sundy,Janice M. Massey,Richard A. Koup,Daniel C. Douek,Dhavalkumar D. Patel,Barton F. Haynes +7 more
TL;DR: A role forThymic cytokines in the process of thymic atrophy is suggested, and IL-7 mRNA expression did not fall with aging in either normal or myasthenia gravis thymuses.
Journal ArticleDOI
Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function
Lucileia Teixeira,Hernan Valdez,Joseph M. McCune,Richard A. Koup,Andrew D. Badley,Andrew D. Badley,Marc K. Hellerstein,Marc K. Hellerstein,Laura A. Napolitano,Daniel C. Douek,Georgina Mbisa,Georgina Mbisa,Steven G. Deeks,Jeffrey M. Harris,Jason D. Barbour,Barry H. Gross,Isaac R. Francis,Robert A. Halvorsen,Robert Asaad,Michael M. Lederman +19 more
TL;DR: Poor CD4 T cell increases observed in some patients with good virologic response to HAART may be caused by failure of thymic T cell production.