Author
Daniel Caminada
Other affiliations: Life Sciences Institute
Bio: Daniel Caminada is an academic researcher from University of Zurich. The author has contributed to research in topics: Efflux & P-glycoprotein. The author has an hindex of 7, co-authored 7 publications receiving 2869 citations. Previous affiliations of Daniel Caminada include Life Sciences Institute.
Papers
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TL;DR: It is shown that only very little is known about long-term effects of pharmaceuticals to aquatic organisms, in particular with respect to biological targets, and targeted ecotoxicological studies are needed focusing on subtle environmental effects.
2,844 citations
TL;DR: This study demonstrates for the first time weak estrogenic activity in vitro of some common pharmaceuticals and their mixtures.
118 citations
TL;DR: Due to the presence of active and inducible ABC transport proteins, the PLHC-1 cells appear to be a reliable in vitro system for the investigation of MDR/MXR mechanisms in fish and correspond well with data from mammalian systems indicating that the specificity and roles of the related efflux transporters may be similar in fish.
50 citations
TL;DR: It is demonstrated that bezafibrate has very little or no effect on PPARα expression andFAO activity, but clofibric acid affects FAO activity.
Abstract: The lipid-lowering agents bezafibrate and clofibric acid, which occur at concentrations up to 3.1 and 1.6 microg/L, respectively, are among the most frequently found human pharmaceuticals in the aquatic environment. In contrast to knowledge about their environmental occurrence, little is known about their effects in the environment. The aim of the present study was to analyze effects of these lipid-lowering agents in fish by focusing on their modes of action, lipid metabolism. Fathead minnows were exposed in aquaria to measured concentrations of 0.1, 1.27, 10.18, 101.56, and 106.7 mg/L bezafibrate and to 1.07, 10.75, and 108.91 mg/L clofibric acid for 14 and 21 d, respectively. After exposure, fish liver was analyzed for expression of peroxisome proliferator-activated receptor alpha (PPARalpha) by quantitative polymerase chain reaction (PCR), and the PPAR-regulated enzyme fatty acyl-coenzyme-A oxidase (FAO) involved in fatty acid oxidation. Bezafibrate had no effect, either on PPARalpha expression or on FAO activity, at all concentrations. In contrast, clofibric acid induced FAO activity in male fathead minnows at 108.91 mg/L. No increase in expression of PPARalpha messenger ribonucleic acid was observed. Egg production was apparently decreased after 21 d of exposure to 108.91 mg/L clofibric acid. The present study demonstrates that bezafibrate has very little or no effect on PPARalpha expression and FAO activity, but clofibric acid affects FAO activity.
44 citations
TL;DR: The presence of ABC transporters in the widely used in vitro fish model, the PLHC-1 hepatoma cell line, and the fact that low micromolar concentrations of specific inhibitors may completely reverse a highly expressed doxorubicin resistance points to the fragility of Pgp1-mediated MXR defence mechanism in fish.
37 citations
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TL;DR: This review provides a summary of the recent occurrence of micropollutants in the aquatic environment including sewage, surface water, groundwater and drinking water.
2,933 citations
TL;DR: Treated wastewater effluents were the main contributors to PPCPs concentrations in the rivers studied, and the effect of WWTP effluent on the quality of river water is significant and cannot be underestimated.
1,436 citations
TL;DR: Nanogram-microgram per litre concentrations are present in groundwater for a large range of EOCs as well as metabolites and transformation products and under certain conditions may pose a threat to freshwater bodies for decades due to relatively long groundwater residence times.
1,353 citations
TL;DR: A review of the current state-of-the-art on PPCPs in the freshwater aquatic environment is presented in this article, where the environmental risk posed by these contaminants is evaluated in light of the persistence, bioaccumulation and toxicity criteria.
1,285 citations
TL;DR: An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented and the different contamination sources as well as fate and both acute and chronic effects on non-target organisms are reviewed.
1,281 citations