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Daniel Compagno
Researcher at Facultad de Ciencias Exactas y Naturales
Publications - 37
Citations - 1148
Daniel Compagno is an academic researcher from Facultad de Ciencias Exactas y Naturales. The author has contributed to research in topics: Prostate cancer & Galectin. The author has an hindex of 18, co-authored 35 publications receiving 988 citations. Previous affiliations of Daniel Compagno include University of Buenos Aires & National Scientific and Technical Research Council.
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Journal ArticleDOI
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease
Diego Jose Laderach,Lucas Daniel Gentilini,Laura Giribaldi,Víctor M. Cárdenas Delgado,Lorena G. Nugnes,Diego O. Croci,Nader Al Nakouzi,Paula Alejandra Sacca,Gabriel Casas,Osvaldo Mazza,Margaret A. Shipp,Elba Vazquez,Anne Chauchereau,Jeffery L. Kutok,Scott J. Rodig,María T. Elola,Daniel Compagno,Gabriel A. Rabinovich +17 more
TL;DR: A dynamically regulated "galectin-specific signature" that accompanies disease evolution in prostate cancer is identified and highlighted, highlighting a major role for Gal-1 as a tractable target for antiangiogenic therapy in advanced stages of the disease.
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Modulation of endothelial cell migration and angiogenesis: a novel function for the “tandem-repeat” lectin galectin-8
Víctor M. Cárdenas Delgado,Lorena G. Nugnes,Lucas L. Colombo,María F. Troncoso,Marisa M. Fernández,Emilio L. Malchiodi,Isabel Frahm,Diego O. Croci,Daniel Compagno,Gabriel A. Rabinovich,Carlota Wolfenstein-Todel,María T. Elola +11 more
TL;DR: It is shown that Gal‐8 is endowed with proangiogeneic properties, and a critical role for this lectin in the regulation of capillary‐tube formation and EC migration is revealed and CD166 [activated leukocyte cell adhesion molecule] was identified as a specificGal‐8‐binding partner in normal vascular ECs.
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RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes.
Magali Berthebaud,Christel Rivière,Peggy Jarrier,Adlen Foudi,Yanyan Zhang,Daniel Compagno,Anne Galy,William Vainchenker,Fawzia Louache +8 more
TL;DR: The data reveal that RGS16 is a negative regulator of CXCR4 signaling in megakaryocytes, and it is postulated that R GS16 regulation is a mechanism that controlsmegakaryocyte maturation by regulating signals from the microenvironment.
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RNA Interference Shows Critical Requirement for NF-κB p50 in the Production of IL-12 by Human Dendritic Cells
Diego Jose Laderach,Daniel Compagno,Olivier Danos,T. William Vainchenker,Anne Galy,Anne Galy +5 more
TL;DR: RNA interference was used to assess the role of the p50 (NF-κB1) protein in the maturation and activation of cultured human monocyte-derived DC, revealing a pivotal requirement for p50 in MoDC for IL-12 production and induction of optimal type-1 immune responses.
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SIRNA-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas.
Daniel Compagno,Carole Merle,Aurélie Morin,Cristèle Gilbert,Jacques Mathieu,Aline Bozec,Claire Mauduit,Mohammed Benahmed,Florence Cabon +8 more
TL;DR: The siRNA-directed silencing of AR, which allows targeting overexpressed as well as mutated isoforms, triggers a strong antitumoral and antiangiogenic effect and opens promising new therapeutic perspectives and tools in advanced and resistant prostate tumors.