Daniel F. Veber

TL;DR: 3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.

TL;DR: A computer modelling and graphics system is used to examine possible alternative molecular fragments and report the synthesis of a highly active cyclic hexapeptide analogue of somatostatin, which results in the observed reduced susceptibility to metabolism by peptidases such as trypsin and has permitted both a long duration of action and oral activity.

TL;DR: An analog of luteinizing hormone-releasing hormone containing a gamma-lactam as a conformational constraint has been prepared with the use of a novel cyclization of a methionine sulfonium salt, and provides evidence for a bioactive conformation containing a beta-turn.

TL;DR: A 99-amino acid HIV-1 protease, produced by chemical synthesis or by expression in bacteria, is shown here to hydrolyze peptides corresponding to all of the known cleavage sites in the HIV- 1 gag and pol polyproteins.

TL;DR: In this article, 3.3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described.