D
Daniel G. Anderson
Researcher at Massachusetts Institute of Technology
Publications - 563
Citations - 71844
Daniel G. Anderson is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Medicine & Gene delivery. The author has an hindex of 121, co-authored 520 publications receiving 59724 citations. Previous affiliations of Daniel G. Anderson include Emory University & Harvard University.
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Knocking down barriers: advances in siRNA delivery
TL;DR: An update on the progress of RNAi therapeutics is provided and novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids are highlighted.
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Non-viral vectors for gene-based therapy
Hao Yin,Rosemary Lynn Kanasty,Ahmed A. Eltoukhy,Arturo J. Vegas,J. Robert Dorkin,Daniel G. Anderson +5 more
TL;DR: The biological barriers to gene delivery in vivo are introduced and recent advances in material sciences, nanotechnology and nucleic acid chemistry that have yielded promising non-viral delivery systems are discussed, some of which are currently undergoing testing in clinical trials.
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Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review.
TL;DR: The main purpose of this review is to elaborate the mechanical and physical properties that affect PLA stability, processability, degradation, PLA-other polymers immiscibility, aging and recyclability, and therefore its potential suitability to fulfill specific application requirements.
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Delivery materials for siRNA therapeutics
TL;DR: An introduction to the biological challenges that siRNA delivery materials aim to overcome is provided, as well as a discussion of the way that the most effective and clinically advanced classes of si RNA delivery systems are designed to surmount these challenges.
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CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
Randall Jeffrey Platt,Sidi Chen,Yang Zhou,Michael Yim,Lukasz Swiech,Hannah R. Kempton,James E. Dahlman,Oren Parnas,Thomas Eisenhaure,Marko Jovanovic,Daniel B. Graham,Siddharth Jhunjhunwala,Matthias Heidenreich,Ramnik J. Xavier,Robert Langer,Daniel G. Anderson,Nir Hacohen,Aviv Regev,Guoping Feng,Phillip A. Sharp,Feng Zhang +20 more
TL;DR: In vivo as well as ex vivo genome editing using adeno-associated virus, lentivirus, or particle-mediated delivery of guide RNA in neurons, immune cells, and endothelial cells is demonstrated, suggesting that Cas9 mice empower a wide range of biological and disease modeling applications.