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Daniel G. Tenen
Researcher at National University of Singapore
Publications - 417
Citations - 41837
Daniel G. Tenen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Transcription factor & Myeloid. The author has an hindex of 103, co-authored 400 publications receiving 38195 citations. Previous affiliations of Daniel G. Tenen include Johns Hopkins University & Boston Children's Hospital.
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Journal ArticleDOI
EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
Susumu Kobayashi,Titus J. Boggon,Tajhal Dayaram,Pasi A. Jänne,Olivier Kocher,Matthew Meyerson,Bruce E. Johnson,Michael J. Eck,Daniel G. Tenen,Balazs Halmos,Balazs Halmos +10 more
TL;DR: In this paper, the authors reported the case of a patient with EGFR-mutant, gefitinib-responsive, advanced non-small-cell lung cancer who had a relapse after two years of complete remission.
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Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak.
Meng-Yuan Dai,Dianbo Liu,Dianbo Liu,Miao Liu,Fuxiang Zhou,Gui-Ling Li,Zhen Chen,Zhi-An Zhang,Hua You,Meng Wu,Qi-Chao Zheng,Yong Xiong,Hui-Hua Xiong,Chun Wang,Chang-Chun Chen,Fei Xiong,Yan Zhang,Ya-Qin Peng,Si-Ping Ge,Bo Zhen,Ting-Ting Yu,Ling Wang,Hua Wang,Yu Liu,Ye-Shan Chen,Jun-Hua Mei,Xiao-Jia Gao,Zhu-Yan Li,Li-Juan Gan,Can He,Zhen Li,Yu-Ying Shi,Yu-Wen Qi,Jing Yang,Daniel G. Tenen,Daniel G. Tenen,Li Chai,Lorelei A. Mucci,Mauricio Santillana,Mauricio Santillana,Hongbing Cai +40 more
TL;DR: In a study of 105 patients with cancer and 536 without, all with confirmed COVID-19, cancer was predictive of more severe disease, with stage IV cancer, hematologic cancer, and lung cancer being associated with worse outcomes.
Journal ArticleDOI
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
Dong-Er Zhang,Pu Zhang,Nai-dy Wang,Christopher J. Hetherington,Gretchen J. Darlington,Daniel G. Tenen +5 more
TL;DR: A model by which transcription factors can direct the differentiation of multipotential precursors through activation of expression of a specific growth factor receptor, allowing proliferation and differentiation in response to a specific extracellular signal is suggested.
Journal ArticleDOI
Dominant-negative mutations of CEBPA , encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
Thomas Pabst,Beatrice U. Mueller,Pu Zhang,Hanna S. Radomska,Sailaja Narravula,Susanne Schnittger,Gerhard Behre,Wolfgang Hiddemann,Daniel G. Tenen +8 more
TL;DR: This is the first report of CEBPA mutations in human neoplasia, and such mutations are likely to induce the differentiation block found in AML.
Journal ArticleDOI
Transcription factors, normal myeloid development, and leukemia.
TL;DR: In the hematopoietic system, stem cells undergo a process of commitment to multipotential progenitors, which in turn give rise to mature blood cells.