Author
Daniel Hamacher
Bio: Daniel Hamacher is an academic researcher from University of Hohenheim. The author has contributed to research in topics: Evolution of eusociality & Neutral theory of molecular evolution. The author has an hindex of 1, co-authored 1 publications receiving 279 citations.
Papers
More filters
Utah State University1, University of Illinois at Urbana–Champaign2, University of Copenhagen3, Johns Hopkins University School of Medicine4, Johns Hopkins University5, University of Chicago6, Hobart and William Smith Colleges7, University of Utah8, United States Department of Agriculture9, Autonomous University of Barcelona10, University of Geneva11, Swiss Institute of Bioinformatics12, Queen Mary University of London13, Martin Luther University of Halle-Wittenberg14, Georgia Institute of Technology15, University of Georgia16, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto17, Sao Paulo State University18, Federal University of São Carlos19, University of São Paulo20, Agricultural Research Service21, East Carolina University22, Ohio Agricultural Research and Development Center23, University of Michigan24, University of Hohenheim25, York University26, Janelia Farm Research Campus27, Texas A&M University28, Harvard University29
TL;DR: There is no single road map to eusociality; independent evolutionary transitions in sociality have independent genetic underpinnings and these transitions do have similar general features, including an increase in constrained protein evolution accompanied by increases in the potential for gene regulation and decreases in diversity and abundance of transposable elements.
Abstract: The evolution of eusociality is one of the major transitions in evolution, but the underlying genomic changes are unknown We compared the genomes of 10 bee species that vary in social complexity, representing multiple independent transitions in social evolution, and report three major findings First, many important genes show evidence of neutral evolution as a consequence of relaxed selection with increasing social complexity Second, there is no single road map to eusociality; independent evolutionary transitions in sociality have independent genetic underpinnings Third, though clearly independent in detail, these transitions do have similar general features, including an increase in constrained protein evolution accompanied by increases in the potential for gene regulation and decreases in diversity and abundance of transposable elements Eusociality may arise through different mechanisms each time, but would likely always involve an increase in the complexity of gene networks
325 citations
Cited by
More filters
28 Jul 2005
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations
854 citations
Journal Article•
[...]
TL;DR: It’s time to get used to the idea that there is no such thing as a safe place to die.
Abstract: 它是美国国立医学图书馆（NLM）生产的国际性生物医学文献联机书目数据库，是美国国立医学图书馆MEDLARS系统30多个数据库中最大的一个数据库，是世界上最著名的生物医学数据库之一。其内容相当于3种印刷本检索刊物：《医学索引》（index medicus，IM）、《牙科文献索引》、《国际护理学索引》，收录了1966年以来的70多个国家4300多种期刊的题录和文摘共1100万条记录，
678 citations
TL;DR: There is unequivocal evidence that ants are the sister group to bees+apoid wasps (Apoidea) and that bees are nested within a paraphyletic Crabronidae, and that taxon choice can fundamentally impact tree topology and clade support in phylogenomic inference.
289 citations
TL;DR: DNA methylation was found to be widespread, detected in all orders examined except Diptera (flies), and a gene duplication event in the maintenance DNA methyltransferase 1 (DNMT1) that is shared by some Hymenoptera, and paralogs have experienced divergent, nonneutral evolution suggests alternative DNA methylation pathways may exist.
Abstract: DNA methylation contributes to gene and transcriptional regulation in eukaryotes, and therefore has been hypothesized to facilitate the evolution of plastic traits such as sociality in insects. However, DNA methylation is sparsely studied in insects. Therefore, we documented patterns of DNA methylation across a wide diversity of insects. We predicted that underlying enzymatic machinery is concordant with patterns of DNA methylation. Finally, given the suggestion that DNA methylation facilitated social evolution in Hymenoptera, we tested the hypothesis that the DNA methylation system will be associated with presence/absence of sociality among other insect orders. We found DNA methylation to be widespread, detected in all orders examined except Diptera (flies). Whole genome bisulfite sequencing showed that orders differed in levels of DNA methylation. Hymenopteran (ants, bees, wasps and sawflies) had some of the lowest levels, including several potential losses. Blattodea (cockroaches and termites) show all possible patterns, including a potential loss of DNA methylation in a eusocial species whereas solitary species had the highest levels. Species with DNA methylation do not always possess the typical enzymatic machinery. We identified a gene duplication event in the maintenance DNA methyltransferase 1 (DNMT1) that is shared by some Hymenoptera, and paralogs have experienced divergent, nonneutral evolution. This diversity and nonneutral evolution of underlying machinery suggests alternative DNA methylation pathways may exist. Phylogenetically corrected comparisons revealed no evidence that supports evolutionary association between sociality and DNA methylation. Future functional studies will be required to advance our understanding of DNA methylation in insects.
259 citations