D
Daniel I. Swerdlow
Researcher at University College London
Publications - 46
Citations - 5493
Daniel I. Swerdlow is an academic researcher from University College London. The author has contributed to research in topics: Mendelian randomization & Genome-wide association study. The author has an hindex of 22, co-authored 42 publications receiving 4192 citations. Previous affiliations of Daniel I. Swerdlow include Imperial College London & Georgetown University.
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Journal ArticleDOI
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
Journal ArticleDOI
Mendelian randomization of blood lipids for coronary heart disease
Michael V. Holmes,Folkert W. Asselbergs,Tom Palmer,Fotios Drenos,Matthew B. Lanktree,Christopher P. Nelson,Caroline Dale,Sandosh Padmanabhan,Chris Finan,Daniel I. Swerdlow,Vinicius Tragante,Erik P A Van Iperen,Suthesh Sivapalaratnam,Sonia Shah,Clara C. Elbers,Tina Shah,Jorgen Engmann,Claudia Giambartolomei,Jon White,Delilah Zabaneh,Reecha Sofat,Stela McLachlan,Pieter A. Doevendans,Anthony J. Balmforth,Alistair S. Hall,Kari E. North,Berta Almoguera,Ron C. Hoogeveen,Mary Cushman,Myriam Fornage,Sanjay R. Patel,Susan Redline,David S. Siscovick,Michael Y. Tsai,Konrad J. Karczewski,Marten H. Hofker,W. M. Monique Verschuren,Michiel L. Bots,Yvonne T. van der Schouw,Olle Melander,Anna F. Dominiczak,Richard W Morris,Yoav Ben-Shlomo,Jackie F. Price,Meena Kumari,Jens Baumert,Annette Peters,Barbara Thorand,Wolfgang Koenig,Tom R. Gaunt,Steve E. Humphries,Robert Clarke,Hugh Watkins,Martin Farrall,James G. Wilson,Stephen S. Rich,Paul I.W. de Bakker,Leslie A. Lange,George Davey Smith,Alexander P. Reiner,Philippa J. Talmud,Mika Kivimäki,Debbie A Lawlor,Frank Dudbridge,Nilesh J. Samani,Brendan J. Keating,Aroon D. Hingorani,Juan P. Casas +67 more
TL;DR: The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain.
Journal ArticleDOI
Association between alcohol and cardiovascular disease:Mendelian randomisation analysis based on individual participant data
Michael V. Holmes,Michael V. Holmes,Caroline Dale,Luisa Zuccolo,Richard J. Silverwood,Yiran Guo,Zheng Ye,David Prieto-Merino,Abbas Dehghan,Stella Trompet,Andrew Wong,Alana Cavadino,Dagmar Drogan,Sandosh Padmanabhan,Shanshan Li,Ajay Yesupriya,Maarten Leusink,Johan Sundström,Jaroslav A. Hubacek,Hynek Pikhart,Daniel I. Swerdlow,Andrie G. Panayiotou,S. A. Borinskaya,Chris Finan,Sonia Shah,Karoline Kuchenbaecker,Tina Shah,Jorgen Engmann,Lasse Folkersen,Per Eriksson,Fulvio Ricceri,Olle Melander,Carlotta Sacerdote,Dale M Gamble,Sruti Rayaprolu,Owen A. Ross,Stela McLachlan,OV Vikhireva,Ivonne Sluijs,Robert A. Scott,Vera Adamkova,Leon Flicker,Frank M. van Bockxmeer,Christine Power,Pedro Marques-Vidal,Tom W. Meade,Michael Marmot,José M. Ferro,Sofia Paulos-Pinheiro,Steve E. Humphries,Philippa J. Talmud,Irene Mateo Leach,Niek Verweij,Allan Linneberg,Tea Skaaby,Pieter A. Doevendans,Maarten J Cramer,Pim van der Harst,Olaf H. Klungel,Nicole F. Dowling,Anna F. Dominiczak,Meena Kumari,Andrew N. Nicolaides,Cornelia Weikert,Heiner Boeing,Shah Ebrahim,Tom R. Gaunt,Jackie F. Price,Lars Lannfelt,Anne Peasey,Ruzena Kubinova,Andrzej Pajak,Sofia Malyutina,Mikhail Voevoda,Mikhail Voevoda,Abdonas Tamosiunas,Anke H. Maitland-van der Zee,Paul Norman,Graeme J. Hankey,Graeme J. Hankey,Manuela M. Bergmann,Albert Hofman,Oscar H. Franco,Jackie A. Cooper,Jutta Palmen,Wilko Spiering,Pim A. de Jong,Diana Kuh,Rebecca Hardy,André G. Uitterlinden,M. Arfan Ikram,Ian Ford,Elina Hyppönen,Elina Hyppönen,Osvaldo P. Almeida,Osvaldo P. Almeida,Nicholas J. Wareham,Kay-Tee Khaw,Anders Hamsten,Anders Hamsten,Lise Lotte N. Husemoen,Anne Tjønneland,Janne Schurmann Tolstrup,Eric B. Rimm,Eric B. Rimm,Joline W.J. Beulens,W. M. Monique Verschuren,N. Charlotte Onland-Moret,Marten H. Hofker,S. Goya Wannamethee,Peter H. Whincup,Richard W Morris,Astrid M. Vicente,Hugh Watkins,Hugh Watkins,Martin Farrall,Martin Farrall,J. Wouter Jukema,James F. Meschia,L. Adrienne Cupples,Stephen J. Sharp,Myriam Fornage,Charles Kooperberg,Andrea Z. LaCroix,James Y. Dai,Matthew B. Lanktree,David S. Siscovick,Eric Jorgenson,Bonnie Spring,Josef Coresh,Yun Li,Sarah G. Buxbaum,Pamela J. Schreiner,R. Curtis Ellison,Michael Y. Tsai,Sanjay R. Patel,Sanjay R. Patel,Susan Redline,Andrew D. Johnson,Ron C. Hoogeveen,Hakon Hakonarson,Jerome I. Rotter,Eric Boerwinkle,Paul I.W. de Bakker,Mika Kivimäki,Folkert W. Asselbergs,Folkert W. Asselbergs,Naveed Sattar,Debbie A Lawlor,John C. Whittaker,John C. Whittaker,George Davey Smith,Kenneth J. Mukamal,Bruce M. Psaty,Bruce M. Psaty,James G. Wilson,Leslie A. Lange,Ajna Hamidovic,Aroon D. Hingorani,Børge G. Nordestgaard,Børge G. Nordestgaard,Martin Bobak,David A. Leon,Claudia Langenberg,Tom Palmer,Alexander P. Reiner,Brendan J. Keating,Brendan J. Keating,Frank Dudbridge,Juan P. Casas,Juan P. Casas +170 more
TL;DR: In this article, the causal role of alcohol consumption in cardiovascular disease was investigated using a Mendelian randomisation meta-analysis of 56 epidemiological studies, including 20 259 coronary heart disease cases and 10 164 stroke events.
Journal ArticleDOI
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Daniel I. Swerdlow,David Preiss,Karoline Kuchenbaecker,Michael V. Holmes,Jorgen Engmann,Tina Shah,Reecha Sofat,Stefan Stender,Paul C. D. Johnson,Robert A. Scott,Maarten Leusink,Niek Verweij,Stephen J. Sharp,Yiran Guo,Claudia Giambartolomei,Christina Chung,Anne Peasey,Antoinette Amuzu,KaWah Li,Jutta Palmen,Philip N. Howard,Jackie A. Cooper,Fotios Drenos,Yun Li,Gordon D.O. Lowe,John Gallacher,Marlene C. W. Stewart,Ioanna Tzoulaki,Sarah G. Buxbaum,Daphne L. van der A,Nita G. Forouhi,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Ruzena Kubinova,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Romanvan Topor-Madry,Urszula Stepaniak,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,Ulf de Faire,Fabrizio Veglia,Ian Ford,J. Wouter Jukema,Rudi G. J. Westendorp,Gert J. de Borst,Pim A. de Jong,Ale Algra,Wilko Spiering,Anke H. Maitland-van der Zee,Olaf H. Klungel,Anthonius de Boer,Pieter A. Doevendans,Charles B. Eaton,Jennifer G. Robinson,David Duggan,John Kjekshus,John R. Downs,Antonio M. Gotto,Anthony C Keech,Roberto Marchioli,Gianni Tognoni,Peter S. Sever,Neil R Poulter,David D. Waters,Terje R. Pedersen,Pierre Amarenco,Haruo Nakamura,John J.V. McMurray,James Lewsey,Daniel I. Chasman,Paul M. Ridker,Aldo P. Maggioni,Luigi Tavazzi,Kausik K. Ray,Sreenivasa Rao Kondapally Seshasai,JoAnn E. Manson,Jackie F. Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Pamela J. Schreiner,Myriam Fornage,David S. Siscovick,Mary Cushman,Meena Kumari,Nicholas J. Wareham,W M Monique Verschuren,Susan Redline,Sanjay R. Patel,John C. Whittaker,Anders Hamsten,Joseph A.C. Delaney,Caroline Dale,Tom R. Gaunt,Andrew Wong,Diana Kuh,Rebecca Hardy,Sekar Kathiresan,Berta Almoguera Castillo,Pim van der Harst,Eric J. Brunner,Anne Tybjærg-Hansen,Michael Marmot,Ronald M. Krauss,Michael Y. Tsai,Josef Coresh,Ron C. Hoogeveen,Bruce M. Psaty,Leslie A. Lange,Hakon Hakonarson,Frank Dudbridge,Steve E. Humphries,Philippa J. Talmud,Mika Kivimäki,Nicholas J. Timpson,Claudia Langenberg,Folkert W. Asselbergs,Mikhail Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Alexander P. Reiner,Brendan J. Keating,Aroon D. Hingorani,Naveed Sattar +132 more
TL;DR: The increased risk of type 2 diabetes noted with statins is at least partially explained by HMGCR inhibition.
Journal ArticleDOI
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Sonia Shah,Albert Henry,Carolina Roselli,Honghuang Lin,G Sveinbjörnsson,Ghazaleh Fatemifar,Åsa K. Hedman,Jemma B. Wilk,Morley Mp,Mark Chaffin,Anna Helgadottir,Niek Verweij,Niek Verweij,Abbas Dehghan,Peter Almgren,C. Andersson,Krishna G. Aragam,Krishna G. Aragam,Johan Ärnlöv,Johan Ärnlöv,Joshua D. Backman,Mary L. Biggs,Heather L. Bloom,Jeff Brandimarto,Michael R. Brown,Leonard Buckbinder,David J. Carey,Daniel I. Chasman,Xu Chen,Jonathan H. Chung,William A. Chutkow,James P. Cook,Graciela E. Delgado,Spiros Denaxas,Alex S. F. Doney,Marcus Dörr,Samuel C. Dudley,Michael E. Dunn,Gunnar Engström,T Esko,T Esko,Stephan B. Felix,Chris Finan,Ian Ford,Mohsen Ghanbari,Sahar Ghasemi,Vilmantas Giedraitis,Franco Giulianini,John S. Gottdiener,Stefan Gross,Daníel F. Guðbjartsson,Daníel F. Guðbjartsson,Rebecca Gutmann,Christopher M. Haggerty,P. van der Harst,Craig L. Hyde,Erik Ingelsson,Joop Jukema,Maryam Kavousi,Khaw K-T.,Marcus E. Kleber,Lars Køber,Andrea Koekemoer,Claudia Langenberg,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Barry London,Luca A. Lotta,Ruth C. Lovering,Jian'an Luan,Patrick K.E. Magnusson,Anubha Mahajan,Kenneth B. Margulies,März W,März W,März W,Olle Melander,Ify R. Mordi,Thomas M. Morgan,Thomas M. Morgan,Andrew D. Morris,Andrew P. Morris,Alanna C. Morrison,Michael W. Nagle,Christopher P. Nelson,Alexander Niessner,Teemu J. Niiranen,Teemu J. Niiranen,Michelle L. O'Donoghue,Anjali T. Owens,Palmer Cna.,Helen M. Parry,Markus Perola,Eliana Portilla-Fernandez,Bruce M. Psaty,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Romaine Spr.,Jerome I. Rotter,Perttu Salo,Veikko Salomaa,J. van Setten,Alaa Shalaby,Diane T. Smelser,Nicholas L. Smith,Steen Stender,David J. Stott,Per Svensson,Tammesoo M-L.,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Guðmundur Thorgeirsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Christian Torp-Pedersen,Stella Trompet,Benoit Tyl,André G. Uitterlinden,André G. Uitterlinden,Abirami Veluchamy,Uwe Völker,Adriaan A. Voors,Xianyuan Wang,Nicholas J. Wareham,Dawn M. Waterworth,P.E Weeke,Raul Weiss,Kerri L. Wiggins,Huilin Xing,Laura M. Yerges-Armstrong,Bing Yu,Faiez Zannad,Jing Hua Zhao,Harry Hemingway,Nilesh J. Samani,McMurray Jjv.,Jian Yang,Peter M. Visscher,Christopher Newton-Cheh,Christopher Newton-Cheh,Anders Mälarstig,Anders Mälarstig,Hilma Holm,Steven A. Lubitz,Steven A. Lubitz,Naveed Sattar,Michael V. Holmes,Michael V. Holmes,Michael V. Holmes,Thomas P. Cappola,Folkert W. Asselbergs,Folkert W. Asselbergs,Aroon D. Hingorani,Karoline Kuchenbaecker,Patrick T. Ellinor,Patrick T. Ellinor,Chim C. Lang,Kari Stefansson,Kari Stefansson,J. G. Smith,J. G. Smith,Ramachandran S. Vasan,Daniel I. Swerdlow,R. T. Lumbers +167 more
TL;DR: Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension.