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Daniel J. Drucker
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 430
Citations - 65500
Daniel J. Drucker is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Glucagon & Glucagon-like peptide-1. The author has an hindex of 123, co-authored 412 publications receiving 58470 citations. Previous affiliations of Daniel J. Drucker include University of North Carolina at Chapel Hill & Mount Sinai Hospital.
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Journal ArticleDOI
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
TL;DR: Clinical trials with the incretin mimetic exenatide and liraglutide show reductions in fasting and postprandial glucose concentrations, and haemoglobin A1c (HbA1c) associated with weight loss, but long-term clinical studies are needed to determine the benefits of targeting the inc retin axis for the treatment of type 2 diabetes.
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Biology of Incretins: GLP-1 and GIP
TL;DR: This review focuses on the mechanisms regulating the synthesis, secretion, biological actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1).
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The biology of incretin hormones.
TL;DR: Current concepts of incretin action are summarized and the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes is highlighted.
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Normalization of obesity-associated insulin resistance through immunotherapy.
Shawn Winer,Yin Chan,Geoffrey Paltser,Dorothy Truong,Hubert Tsui,Jasmine Bahrami,Ruslan Dorfman,Yongqian Wang,Julian Zielenski,Fabrizio G. Mastronardi,Yuko Maezawa,Daniel J. Drucker,Edgar G. Engleman,Daniel A. Winer,H.-Michael Dosch +14 more
TL;DR: It is discovered that CD4+ T lymphocytes, resident in visceral adipose tissue (VAT), control insulin resistance in mice with diet-induced obesity (DIO), andalyses of human tissue suggest that a similar process may also occur in humans.
Journal ArticleDOI
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Melina Claussnitzer,Simon N. Dankel,Kyoung-Han Kim,Gerald Quon,Wouter Meuleman,Christine Haugen,Viktoria Glunk,Isabel S. Sousa,Jacqueline L. Beaudry,Vijitha Puviindran,Nezar Abdennur,Jannel Liu,Per-Arne Svensson,Yi-Hsiang Hsu,Daniel J. Drucker,Gunnar Mellgren,Chi-chung Hui,Hans Hauner,Manolis Kellis,Manolis Kellis +19 more
TL;DR: The data indicate that the FTO allele associated with obesity represses mitochondrial thermogenesis in adipocyte precursor cells in a tissue-autonomous manner, and points to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-ob obesity effects.