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Daniel J. Hassett
Researcher at University of Cincinnati Academic Health Center
Publications - 170
Citations - 13789
Daniel J. Hassett is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Pseudomonas aeruginosa & Mutant. The author has an hindex of 61, co-authored 167 publications receiving 12602 citations. Previous affiliations of Daniel J. Hassett include University of Maryland, Baltimore & Veterans Health Administration.
Papers
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Journal ArticleDOI
Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa
Nicolas Barraud,Daniel J. Hassett,Sung Hei Hwang,Scott A. Rice,Staffan Kjelleberg,Jeremy S. Webb,Jeremy S. Webb +6 more
TL;DR: It is demonstrated that exposure to SNP greatly enhanced the efficacy of antimicrobial compounds in the removal of established P. aeruginosa biofilms from a glass surface and combined exposure to both NO and antimicrobial agents may offer a novel strategy to control preestablished, persistent P. aerobicaerobic bacteria.
Journal ArticleDOI
The role of pyocyanin in Pseudomonas aeruginosa infection
TL;DR: This review briefly highlights recent advances that might clarify the role of PCN in P. aeruginosa pathogenesis.
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Pseudomonas aeruginosa Anaerobic Respiration in Biofilms: Relationships to Cystic Fibrosis Pathogenesis
Sang Sun Yoon,Robert F. Hennigan,George M. Hilliard,Urs A. Ochsner,Kislay Parvatiyar,Moneesha C. Kamani,Holly L. Allen,Teresa R. DeKievit,Paul R. Gardner,Ute E. Schwab,John J. Rowe,Barbara H. Iglewski,Timothy R. McDermott,Ronald P. Mason,Daniel J. Wozniak,Robert E. W. Hancock,Matthew R. Parsek,Terry L. Noah,Richard C. Boucher,Daniel J. Hassett +19 more
TL;DR: P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide reductase to modulate or prevent accumulation of toxic NO, a byproduct of anaerilic respiration.
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The Exopolysaccharide Alginate Protects Pseudomonas aeruginosa Biofilm Bacteria from IFN-γ-Mediated Macrophage Killing
Jeff G. Leid,Carey J. Willson,Mark E. Shirtliff,Daniel J. Hassett,Matthew R. Parsek,Alyssa K. Jeffers +5 more
TL;DR: The results suggest that although alginate may not play a significant role in bacterial attachment, biofilm development, and formation, it may play an important role in protecting mucoid P. aeruginosa biofilm bacteria from the human immune system.
Journal ArticleDOI
Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic Di-GMP levels, and enhanced dispersal
N. Barraud,David Schleheck,Janosch Klebensberger,Jeremy S. Webb,Daniel J. Hassett,Scott A. Rice,Staffan Kjelleberg +6 more
TL;DR: A role for c-di-GMP signaling in triggering the biofilm dispersal event induced by NO is suggested, as dispersal requires PDE activity and addition of NO stimulates PDE and induces the concomitant decrease in intracellular c- DiGMP levels in P. aeruginosa.