D
Daniel M. Frey
Researcher at University Hospital of Basel
Publications - 39
Citations - 1863
Daniel M. Frey is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Cytotoxic T cell & Interleukin 21. The author has an hindex of 19, co-authored 35 publications receiving 1662 citations. Previous affiliations of Daniel M. Frey include University of Basel & Washington University in St. Louis.
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Journal ArticleDOI
Clinical impact of programmed cell death ligand 1 expression in colorectal cancer.
Raoul A. Droeser,Raoul A. Droeser,Christian Hirt,Christian Hirt,Carsten T. Viehl,Daniel M. Frey,Christian A. Nebiker,Christian A. Nebiker,Xaver Huber,Inti Zlobec,Serenella Eppenberger-Castori,Alexander Tzankov,Raffaele Rosso,Markus Zuber,Manuele G. Muraro,Francesca Amicarella,Eleonora Cremonesi,Michael Heberer,Giandomenica Iezzi,Alessandro Lugli,Luigi Terracciano,Giuseppe Sconocchia,Daniel Oertli,Giulio C. Spagnoli,Luigi Tornillo +24 more
TL;DR: Interestingly, programmed death receptor ligand 1 (PDL-1) and interferon (IFN)-γ gene expression, as detected by quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in fresh frozen CRC specimens were found to be significantly associated with improved survival in MMR-proficient CRC.
Journal ArticleDOI
High frequency of tumor‐infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair‐proficient colorectal cancer patients
Daniel M. Frey,Raoul A. Droeser,Carsten T. Viehl,Inti Zlobec,Alessandro Lugli,Urs Zingg,Daniel Oertli,Christoph Kettelhack,Luigi Terracciano,Luigi Tornillo +9 more
TL;DR: High frequency of tumor‐infiltrating FOXP3+ Treg is associated with early T stage and independently predicts improved disease‐specific survival in MMR‐proficient CRC patients.
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Depletion of CD4+CD25+ regulatory T cells promotes a tumor-specific immune response in pancreas cancer-bearing mice.
Carsten T. Viehl,Carsten T. Viehl,Todd T. Moore,Udaya K. Liyanage,Daniel M. Frey,Daniel M. Frey,Jesmin P. Ehlers,Timothy J. Eberlein,Peter S. Goedegebuure,David C. Linehan +9 more
TL;DR: Depletion of Treg alone or in combination with a whole tumor cell vaccine promotes a tumor-specific immune response and strategies incorporating Treg depletion might improve the efficacy of cancer vaccines.
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Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma.
Udaya K. Liyanage,Peter S. Goedegebuure,Todd T. Moore,Carsten T. Viehl,Tricia A. Moo-Young,Justin W. Larson,Daniel M. Frey,Jesmin P. Ehlers,Timothy J. Eberlein,David C. Linehan +9 more
TL;DR: It is concluded that Pan02 tumor promotes the prevalence of Treg, in part through the secretion of TGF-β, which may result in immune evasion.
Journal ArticleDOI
High myeloperoxidase positive cell infiltration in colorectal cancer is an independent favorable prognostic factor
Raoul A. Droeser,Raoul A. Droeser,Christian Hirt,Christian Hirt,Serenella Eppenberger-Castori,Inti Zlobec,Carsten T. Viehl,Daniel M. Frey,Christian A. Nebiker,Raffaele Rosso,Markus Zuber,Francesca Amicarella,Giandomenica Iezzi,Giuseppe Sconocchia,Michael Heberer,Alessandro Lugli,Luigi Tornillo,Daniel Oertli,Luigi Terracciano,Giulio C. Spagnoli +19 more
TL;DR: High density MPO+ cell infiltration is a novel independent favorable prognostic factor in CRC and proves an independent prognostic marker overall.