D
Daniel M. Jordan
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 51
Citations - 6703
Daniel M. Jordan is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Population & Negative selection. The author has an hindex of 20, co-authored 45 publications receiving 5414 citations. Previous affiliations of Daniel M. Jordan include Brigham and Women's Hospital & Harvard University.
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Predicting Functional Effect of Human Missense Mutations Using PolyPhen-2
TL;DR: PolyPhen‐2 (Polymorphism Phenotyping v2), available as software and via a Web server, predicts the possible impact of amino acid substitutions on the stability and function of human proteins using structural and comparative evolutionary considerations.
Journal ArticleDOI
Evolution and functional impact of rare coding variation from deep sequencing of human exomes
Jacob A. Tennessen,Abigail W. Bigham,Timothy D. O’Connor,Wenqing Fu,Eimear E. Kenny,Simon Gravel,Sean McGee,Ron Do,Ron Do,Xiaoming Liu,Goo Jun,Hyun Min Kang,Daniel M. Jordan,Suzanne M. Leal,Stacey Gabriel,Mark J. Rieder,Gonçalo R. Abecasis,David Altshuler,Deborah A. Nickerson,Eric Boerwinkle,Eric Boerwinkle,Shamil R. Sunyaev,Shamil R. Sunyaev,Carlos Bustamante,Michael J. Bamshad,Joshua M. Akey +25 more
TL;DR: The findings suggest that most human variation is rare, not shared between populations, and that rare variants are likely to play a role in human health, and show that large sample sizes will be required to associate rare variants with complex traits.
Journal ArticleDOI
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
Nidhi Sahni,Song Yi,Mikko Taipale,Juan I. Fuxman Bass,Jasmin Coulombe-Huntington,Fan Yang,Fan Yang,Jian Peng,Jochen Weile,Jochen Weile,Georgios I. Karras,Yang Wang,István Kovács,István Kovács,Atanas Kamburov,Irina Krykbaeva,Mandy H. Y. Lam,George Tucker,Vikram Khurana,Amitabh Sharma,Amitabh Sharma,Yang-Yu Liu,Yang-Yu Liu,Nozomu Yachie,Nozomu Yachie,Quan Zhong,Yun Shen,Alexandre Palagi,Adriana San-Miguel,Changyu Fan,Dawit Balcha,Amélie Dricot,Daniel M. Jordan,Jennifer M. Walsh,Akash A. Shah,Xinping Yang,Ani K. Stoyanova,Alex Leighton,Michael A. Calderwood,Yves Jacob,Yves Jacob,Michael E. Cusick,Kourosh Salehi-Ashtiani,Luke Whitesell,Shamil R. Sunyaev,Shamil R. Sunyaev,Bonnie Berger,Albert-László Barabási,Albert-László Barabási,Benoit Charloteaux,David E. Hill,Tong Hao,Frederick P. Roth,Frederick P. Roth,Frederick P. Roth,Yu Xia,Yu Xia,Albertha J.M. Walhout,Albertha J.M. Walhout,Susan Lindquist,Susan Lindquist,Marc Vidal +61 more
TL;DR: This work functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays, suggesting that disease-associated alleles that perturb distinct protein activities rather than grossly affecting folding and stability are relatively widespread.
Journal ArticleDOI
Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii
Inge Seim,Xiaodong Fang,Zhiqiang Xiong,Alexey V. Lobanov,Zhiyong Huang,Siming Ma,Yue Feng,Anton A. Turanov,Yabing Zhu,Tobias L. Lenz,Maxim V. Gerashchenko,Maxim V. Gerashchenko,Dingding Fan,Sun Hee Yim,Xiaoming Yao,Daniel M. Jordan,Yingqi Xiong,Yong Ma,Andrey N. Lyapunov,Guanxing Chen,Oksana I. Kulakova,Yudong Sun,Sang-Goo Lee,Roderick T. Bronson,Alexey Moskalev,Alexey Moskalev,Alexey Moskalev,Shamil R. Sunyaev,Guojie Zhang,Anders Krogh,Jun Wang,Vadim N. Gladyshev,Vadim N. Gladyshev +32 more
TL;DR: The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt's bat.
Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii
Inge Seim,Xiaodong Fang,Zhiqiang Xiong,Alexey V. Lobanov,Zhiyong Huang,Siming Ma,Yue Feng,Anton A. Turanov,Yabing Zhu,Tobias L. Lenz,Maxim V. Gerashchenko,Maxim V. Gerashchenko,Dingding Fan,Sun Hee Yim,Xiaoming Yao,Daniel M. Jordan,Yingqi Xiong,Yong Ma,Andrey N. Lyapunov,Guanxing Chen,Oksana I. Kulakova,Yudong Sun,Sang-Goo Lee,Roderick T. Bronson,Alexey Moskalev,Alexey Moskalev,Alexey Moskalev,Shamil R. Sunyaev,Guojie Zhang,Anders Krogh,Jun Wang,Vadim N. Gladyshev,Vadim N. Gladyshev +32 more
TL;DR: The Brandt's bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4.8 kg adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity as discussed by the authors.