D
Daniel P.K. Ng
Researcher at National University of Singapore
Publications - 42
Citations - 4221
Daniel P.K. Ng is an academic researcher from National University of Singapore. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 27, co-authored 42 publications receiving 3989 citations. Previous affiliations of Daniel P.K. Ng include Harvard University & Joslin Diabetes Center.
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Journal ArticleDOI
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
Hiroyuki Unoki,Atsushi Takahashi,Takahisa Kawaguchi,Kazuo Hara,Momoko Horikoshi,Gitte Andersen,Daniel P.K. Ng,Johan Holmkvist,Knut Borch-Johnsen,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Annelli Sandbæk,Torsten Lauritzen,Torben Hansen,Siti Nurbaya,Tatsuhiko Tsunoda,Michiaki Kubo,Tetsuya Babazono,Hiroshi Hirose,Matsuhiko Hayashi,Yasuhiko Iwamoto,Atsunori Kashiwagi,Kohei Kaku,Ryuzo Kawamori,E. Shyong Tai,Oluf Pedersen,Oluf Pedersen,Naoyuki Kamatani,Takashi Kadowaki,Ryuichi Kikkawa,Yusuke Nakamura,Shiro Maeda +32 more
TL;DR: A genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 1 diabetes.
Journal ArticleDOI
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
Yoon Shin Cho,Chien Hsiun Chen,Chien Hsiun Chen,Cheng Hu,Jirong Long,Rick Twee-Hee Ong,Xueling Sim,Fumihiko Takeuchi,Ying Wu,Min Jin Go,Toshimasa Yamauchi,Yi-Cheng Chang,Soo Heon Kwak,Ronald C.W. Ma,Ken Yamamoto,Linda S. Adair,Tin Aung,Qiuyin Cai,Li Ching Chang,Yuan-Tsong Chen,Yu-Tang Gao,Frank B. Hu,Hyung Lae Kim,Sangsoo Kim,Young-Jin Kim,Jeannette Lee,Nanette R. Lee,Yun Li,Jianjun Liu,Wei Lu,Jiro Nakamura,Eitaro Nakashima,Daniel P.K. Ng,Wan Ting Tay,Fuu Jen Tsai,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Mitsuhiro Yokota,Wei Zheng,Rong Zhang,Congrong Wang,Wing-Yee So,Keizo Ohnaka,Hiroshi Ikegami,Hara Kazuo,Young Min Cho,Nam H. Cho,Tien-Jyun Chang,Yuqian Bao,Åsa K. Hedman,Andrew P. Morris,Mark I. McCarthy,Ryoichi Takayanagi,Kyong Soo Park,Weiping Jia,Lee-Ming Chuang,Juliana C.N. Chan,Shiro Maeda,Takashi Kadowaki,Jong-Young Lee,Jer-Yuarn Wu,Jer-Yuarn Wu,Yik Ying Teo,Yik Ying Teo,E. Shyong Tai,Xiao-Ou Shu,Karen L. Mohlke,Norihiro Kato,Bok Ghee Han,Mark Seielstad,Mark Seielstad,Mark Seielstad +72 more
TL;DR: The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.
Journal ArticleDOI
Meta-analysis identifies common variants associated with body mass index in east Asians
Wanqing Wen,Yoon Shin Cho,Wei Zheng,Rajkumar Dorajoo,Rajkumar Dorajoo,Norihiro Kato,Lu Qi,Chien Hsiun Chen,Chien Hsiun Chen,Ryan J. Delahanty,Yukinori Okada,Yasuharu Tabara,Dongfeng Gu,Dingliang Zhu,Christopher A. Haiman,Zengnan Mo,Yu Tang Gao,Seang-Mei Saw,Min Jin Go,Fumihiko Takeuchi,Li Ching Chang,Yoshihiro Kokubo,Jun Liang,Mei Hao,Loic Le Marchand,Yi Zhang,Yanling Hu,Tien Yin Wong,Tien Yin Wong,Jirong Long,Bok Ghee Han,Michiaki Kubo,Ken Yamamoto,Mei Hsin Su,Tetsuro Miki,Brian E. Henderson,Huai-Dong Song,Aihua Tan,Jiang He,Daniel P.K. Ng,Qiuyin Cai,Tatsuhiko Tsunoda,Fuu Jen Tsai,Naoharu Iwai,Gary K. Chen,Jiajun Shi,Jianfeng Xu,Xueling Sim,Yong-Bing Xiang,Shiro Maeda,Rick Twee-Hee Ong,Rick Twee-Hee Ong,Chun Li,Yusuke Nakamura,Tin Aung,Tin Aung,Naoyuki Kamatani,Jianjun Liu,Wei Lu,Mitsuhiro Yokota,Mitsuhiro Yokota,Mark Seielstad,Mark Seielstad,Cathy S.J. Fann,Cathy S.J. Fann,Jer-Yuarn Wu,Jer-Yuarn Wu,Jong-Young Lee,Frank B. Hu,Toshihiro Tanaka,E. Shyong Tai,Xiao-Ou Shu +71 more
TL;DR: A meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians and three additional loci nearly reached the genome-wide significance threshold may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.
Journal ArticleDOI
Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes
Marcus G. Pezzolesi,G. David Poznik,Josyf C. Mychaleckyj,Andrew D. Paterson,Michelle T. Barati,Jon B. Klein,Daniel P.K. Ng,Grzegorz Placha,Luis Henrique Santos Canani,Jacek Bochenski,Daryl Waggott,Michael L. Merchant,Bozena Krolewski,Lucia Mirea,Krzysztof Wanic,Pisut Katavetin,Masahiko Kure,Paweł Wołkow,Jonathon Dunn,Adam M. Smiles,William H. Walker,Andrew P. Boright,Shelley B. Bull,Alessandro Doria,John J. Rogus,Stephen S. Rich,James H. Warram,Andrzej S. Krolewski +27 more
TL;DR: Genetic associations for susceptibility to diabetic nephropathy are identified at two novel candidate loci near the FRMD3 and CARS genes, which implicates previously unsuspected pathways in the pathogenesis of this important late complication of type 1 diabetes.
Journal ArticleDOI
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
Toshimasa Yamauchi,Hara Kazuo,Shiro Maeda,Kazuki Yasuda,Atsushi Takahashi,Momoko Horikoshi,Masahiro Nakamura,Hayato Fujita,Niels Grarup,Stéphane Cauchi,Daniel P.K. Ng,Ronald C.W. Ma,Tatsuhiko Tsunoda,Michiaki Kubo,Hirotaka Watada,Hiroshi Maegawa,Miki Okada-Iwabu,Masato Iwabu,Nobuhiro Shojima,Hyoung Doo Shin,Gitte Andersen,Daniel R. Witte,Daniel R. Witte,Torben Jørgensen,Torsten Lauritzen,Annelli Sandbæk,Torben Hansen,Torben Hansen,Toshihiko Ohshige,Shintaro Omori,Ikuo Saito,Kohei Kaku,Hiroshi Hirose,Wing-Yee So,Delphine Beury,Juliana C.N. Chan,Kyong Soo Park,E. Shyong Tai,Chikako Ito,Yasushi Tanaka,Atsunori Kashiwagi,Ryuzo Kawamori,Masato Kasuga,Philippe Froguel,Philippe Froguel,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Naoyuki Kamatani,Yusuke Nakamura,Takashi Kadowaki +50 more
TL;DR: Two new loci at UBE2E2 and C2CD4A-C2 CD4B associated with susceptibility to T2D are identified and replicated in other east Asian populations.