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Daniel R. Franken

Researcher at Stellenbosch University

Publications -  97
Citations -  3459

Daniel R. Franken is an academic researcher from Stellenbosch University. The author has contributed to research in topics: Sperm & Zona pellucida. The author has an hindex of 35, co-authored 97 publications receiving 3220 citations. Previous affiliations of Daniel R. Franken include University of the Western Cape & Tygerberg Hospital.

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Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Ashok Agarwal, +96 more
TL;DR: Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants) and may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose.
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Acrosomal morphology as a novel criterion for male fertility diagnosis: relation with acrosin activity, morphology (strict criteria), and fertilization in vitro *

TL;DR: In this article, the relationship between sperm acrosin activity, sperm morphology evaluated according to strict criteria, visually observed acrosomal morphology, and IVF rates was determined on all semen samples together with a standard semen analysis.
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A new computerized method of reading sperm morphology (strict criteria) is as efficient as technician reading.

TL;DR: There is a positive and significant correlation between FERTECH evaluation and manual assessment of sperm morphology and the reproducibility of the computerized method and the ability to distinguish between fertile and subfertile groups using those criteria are good.
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The hemizona assay (HZA): a predictor of human sperm fertilizing potential in in vitro fertilization (IVF) treatment.

TL;DR: Assessment of the relationship between sperm binding to the hemizona and in vitro fertilization (IVF) success enhanced confidence that the HZA is diagnostic for identification of patients at high risk of failing to achieve fertilization in vitro.
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Sperm function assays and their predictive value for fertilization outcome in IVF therapy: a meta-analysis

TL;DR: An objective, outcome-based examination of the validity of the currently available assays demonstrated a high predictive power of the sperm-zona pellucida binding and the induced-acrosome reaction assays for fertilization outcome, but indicated a poor clinical value of the SPA as predictor of fertilization.