D
Daniel S. Kohane
Researcher at Boston Children's Hospital
Publications - 279
Citations - 24096
Daniel S. Kohane is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Drug delivery & Nerve block. The author has an hindex of 72, co-authored 269 publications receiving 21282 citations. Previous affiliations of Daniel S. Kohane include Brigham and Women's Hospital & Massachusetts Institute of Technology.
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Journal ArticleDOI
Hydrogels in drug delivery: progress and challenges
Todd Hoare,Daniel S. Kohane +1 more
TL;DR: Recent progress in overcoming challenges with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs fromhydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches is discussed.
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Nanotechnological strategies for engineering complex tissues.
TL;DR: The nanocomposite nature of the extracellular matrix is reviewed, the design considerations for different tissues are described, and the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues are discussed.
Journal ArticleDOI
Engineering vascularized skeletal muscle tissue.
Shulamit Levenberg,Shulamit Levenberg,Jeroen Rouwkema,Mara L. Macdonald,Evan S. Garfein,Daniel S. Kohane,Diane C. Darland,Robert P. Marini,Clemens van Blitterswijk,Richard C. Mulligan,Patricia A. D'Amore,Robert Langer +11 more
TL;DR: The induction of endothelial vessel networks in engineered skeletal muscle tissue constructs using a three-dimensional multiculture system consisting of myoblasts, embryonic fibroblasts and endothelial cells coseeded on highly porous, biodegradable polymer scaffolds is described.
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Nanowired three-dimensional cardiac patches
Tal Dvir,Tal Dvir,Brian P. Timko,Brian P. Timko,Mark D. Brigham,Shreesh R. Naik,Sandeep S. Karajanagi,Sandeep S. Karajanagi,Oren Levy,Oren Levy,Hongwei Jin,Kevin Kit Parker,Robert Langer,Daniel S. Kohane +13 more
TL;DR: It is shown that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls ofAlginate and improve electrical communication between adjacent cardiac cells.
Journal ArticleDOI
Remotely triggerable drug delivery systems.
TL;DR: A review of triggerable materials that range in scale from nano to macro, and are activated by a range of stimuli, that may enhance therapeutic effectiveness and reduce systemic toxicity.