Author
Daniel Swern
Other affiliations: DuPont
Bio: Daniel Swern is an academic researcher from Temple University. The author has contributed to research in topics: Fatty acid & Polyunsaturated fatty acid. The author has an hindex of 36, co-authored 205 publications receiving 7297 citations. Previous affiliations of Daniel Swern include DuPont.
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1,525 citations
TL;DR: In this paper, the oxidation of primary, secondary, allylic, benzylic, hindered and bicyclic alcohols with dimethyl sulfoxide (DMSO) activated by numerous electrophiles was studied: yields of carbonyls, byproducts and recovered alcohols were quantitatively determined.
1,104 citations
819 citations
206 citations
182 citations
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TL;DR: Dehydroisomerization of Limonene and Terpenes To Produce Cymene 2481 4.2.1.
Abstract: 3.2.3. Hydroformylation 2467 3.2.4. Dimerization 2468 3.2.5. Oxidative Cleavage and Ozonolysis 2469 3.2.6. Metathesis 2470 4. Terpenes 2472 4.1. Pinene 2472 4.1.1. Isomerization: R-Pinene 2472 4.1.2. Epoxidation of R-Pinene 2475 4.1.3. Isomerization of R-Pinene Oxide 2477 4.1.4. Hydration of R-Pinene: R-Terpineol 2478 4.1.5. Dehydroisomerization 2479 4.2. Limonene 2480 4.2.1. Isomerization 2480 4.2.2. Epoxidation: Limonene Oxide 2480 4.2.3. Isomerization of Limonene Oxide 2481 4.2.4. Dehydroisomerization of Limonene and Terpenes To Produce Cymene 2481
5,127 citations
1,398 citations
TL;DR: In this paper, the oxidation of primary, secondary, allylic, benzylic, hindered and bicyclic alcohols with dimethyl sulfoxide (DMSO) activated by numerous electrophiles was studied: yields of carbonyls, byproducts and recovered alcohols were quantitatively determined.
1,104 citations
TL;DR: The fundamental concepts underlying the principles of green and sustainable chemistry--atom and step economy and the E factor--are presented, within the general context of efficiency in organic synthesis, and the transition from fossil-based chemicals manufacture to a more sustainable biomass-based production is discussed.
Abstract: In this tutorial review, the fundamental concepts underlying the principles of green and sustainable chemistry - atom and step economy and the E factor - are presented, within the general context of efficiency in organic synthesis. The importance of waste minimisation through the widespread application of catalysis in all its forms – homogeneous, heterogeneous, organocatalysis and biocatalysis – is discussed. These general principles are illustrated with simple practical examples, such as alcohol oxidation and carbonylation and the asymmetric reduction of ketones. The latter reaction is exemplified by a three enzyme process for the production of a key intermediate in the synthesis of the cholesterol lowering agent, atorvastatin. The immobilisation of enzymes as cross-linked enzyme aggregates (CLEAs) as a means of optimizing operational performance is presented. The use of immobilised enzymes in catalytic cascade processes is illustrated with a trienzymatic process for the conversion of benzaldehyde to (S)-mandelic acid using a combi-CLEA containing three enzymes. Finally, the transition from fossil-based chemicals manufacture to a more sustainable biomass-based production is discussed.
1,095 citations
TL;DR: In this article, the authors describe the development of two of those education tools, which are used to influence and improve the environmental performance of a large multi-national pharmaceutical company by using electronic education tools.
845 citations