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Daniela F. Quail
Researcher at McGill University
Publications - 47
Citations - 10958
Daniela F. Quail is an academic researcher from McGill University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 17, co-authored 29 publications receiving 7588 citations. Previous affiliations of Daniela F. Quail include Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Microenvironmental regulation of tumor progression and metastasis.
TL;DR: The paradoxical roles of the tumor microenvironment during specific stages of cancer progression and metastasis are discussed, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
Journal ArticleDOI
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Stephanie M. Pyonteck,Leila Akkari,Alberto J. Schuhmacher,Robert L. Bowman,Lisa Sevenich,Daniela F. Quail,Oakley C. Olson,Marsha L. Quick,Jason T. Huse,Virginia Teijeiro,Manu Setty,Christina S. Leslie,Yoko Oei,Alicia Pedraza,Jianan Zhang,Cameron Brennan,James Sutton,Eric C. Holland,Dylan Daniel,Johanna A. Joyce +19 more
TL;DR: The results identify TAMs as a promising therapeutic target for proneural gliomas and establish the translational potential of CSF-1R inhibition for GBM.
Journal ArticleDOI
The Microenvironmental Landscape of Brain Tumors
TL;DR: A number of distinct features of the brain tumor microenvironment are discussed, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment.
Journal ArticleDOI
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
Daniela F. Quail,Robert L. Bowman,Leila Akkari,Leila Akkari,Leila Akkari,Marsha L. Quick,Alberto J. Schuhmacher,Jason T. Huse,Eric C. Holland,James Sutton,Johanna A. Joyce,Johanna A. Joyce,Johanna A. Joyce +12 more
TL;DR: It is shown that although overall survival is significantly prolonged in response to CSF-1R inhibition, tumors recur eventually in >50% of mice, indicating the necessity of combination therapy to expose PI3K signaling dependency in recurrent disease.
Journal ArticleDOI
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
Robert L. Bowman,Florian Klemm,Florian Klemm,Florian Klemm,Leila Akkari,Leila Akkari,Leila Akkari,Stephanie M. Pyonteck,Lisa Sevenich,Daniela F. Quail,Surajit Dhara,Kenishana Simpson,Eric E. Gardner,Christine A. Iacobuzio-Donahue,Cameron Brennan,Viviane Tabar,Philip H. Gutin,Johanna A. Joyce,Johanna A. Joyce,Johanna A. Joyce +19 more
TL;DR: The data indicate that distinct transcriptional networks in brain-resident microglia and recruited BMDMs are associated with tumor-mediated education yet are also influenced by chromatin landscapes established before tumor initiation.