Daniela Herrera Moro Chao

TL;DR: In this article, the authors chart the history of the melanocortin pathway, explore its pharmacology, genetics and physiology, and tell the story of how a neuropeptidergic circuit managed to find its way to becoming an important druggable obesity target.

TL;DR: In this paper , the authors demonstrate that liraglutide is shuttled to target cells in the mouse hypothalamus by specialized ependymoglial cells called tanycytes, bypassing the blood-brain barrier.

TL;DR: It is shown that obesity promotes anatomically restricted remodeling of hypothalamic astrocyte activity, which becomes defective in obesity, and potential targets for anti-obesity strategy are suggested.

TL;DR: Evidence that peripheral insulin administration modulates the action of GLP-1R agonists onto fatty acids oxidation is provided, finding that in human subjects, low blood glucose also correlates with enhanced blood-to-brain passage of insulin suggesting that changes in glycaemia also affect passage of peptide hormones into the brain in humans.

TL;DR: In this article , the authors show that exposure to enriched food leads to profound changes in neuronal activity and synchrony and reveal a yet unappreciated role for striatal astrocyte as a direct operator of reward-driven behavior and metabolic control.