Daniela Riccardi

TL;DR: The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.

TL;DR: In rat kidney, Northern analysis revealed RaKCaR transcripts of 4 and 7 kb, and in situ hybridization showed localization primarily in outer medulla and cortical medullary rays, which provide important insights into the molecular structure of an extracellular Ca2+/polyvalent cation-sensing receptor in rat kidney.

TL;DR: It is demonstrated that RaKCaR protein is expressed in many different nephron segments and that the polarity of receptor expression varies with cell type along the nephrons, suggesting potential roles for the extracellular Ca2+/polyvalent cation-sensing receptor in responding to both circulating and urinary concentrations of divalent minerals and potentially other polyvalENT cations.

TL;DR: The findings raise the possibility of roles for RaKCaR not only in the regulation of divalent mineral re absorption but also in water reabsorption and urinary concentration, and provide new insights in understanding the effects of hypercalcemia on hormone-stimulated salt and water transport.

TL;DR: The results reveal CaR expression in several cell types of small and large intestine, in which it may modulate absorptive and/or secretomotor functions.