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Daniela Secci
Researcher at Sapienza University of Rome
Publications - 175
Citations - 5927
Daniela Secci is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Monoamine oxidase & Carbon suboxide. The author has an hindex of 39, co-authored 171 publications receiving 5152 citations. Previous affiliations of Daniela Secci include University of Cagliari.
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Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives
TL;DR: In this article, the synthesis and biological activity of heterocyclic compounds synthesized by carbon suboxide was investigated and some 2-oxo (2H) 1-benzopyran-3-carboxamide derivatives were screened.
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Chalcones: a valid scaffold for monoamine oxidases inhibitors.
Franco Chimenti,Rossella Fioravanti,Adriana Bolasco,Paola Chimenti,Daniela Secci,Francesca Rossi,Matilde Yáñez,Francisco Orallo,Francesco Ortuso,Stefano Alcaro +9 more
TL;DR: The docking technique provided new insight on the inhibition mechanism and the rational drug design of more potent/selective hMAO inhibitors based on the chalcone scaffold.
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Synthesis, Molecular Modeling, and Selective Inhibitory Activity against Human Monoamine Oxidases of 3-Carboxamido-7-Substituted Coumarins†
Franco Chimenti,Daniela Secci,Adriana Bolasco,Paola Chimenti,Bruna Bizzarri,Arianna Granese,Simone Carradori,Matilde Yáñez,Francisco Orallo,Francesco Ortuso,Stefano Alcaro +10 more
TL;DR: To better understand the enzyme-inhibitor interaction and to explain the selectivity of the most active compounds toward hMAOs, molecular modeling studies were carried out on new, high resolution, hMAO-A and h MAO-B crystallographic structures.
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Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein.
Fedele Manna,Franco Chimenti,Rossella Fioravanti,Adriana Bolasco,Daniela Secci,Paola Chimenti,Cristiano Ferlini,Giovanni Scambia +7 more
TL;DR: A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region.
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Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: Extraction, biological analysis, and computational study
Franco Chimenti,Filippo Cottiglia,Leonardo Bonsignore,Laura Casu,Mariano Casu,Costantino Floris,Daniela Secci,Adriana Bolasco,Paola Chimenti,Arianna Granese,Olivia Befani,Paola Turini,Stefano Alcaro,Francesco Ortuso,G. Trombetta,and Alberto Loizzo,Irene Guarino +16 more
TL;DR: The methanol extract from Hypericum hircinum leaves exhibited in vitro inhibition of monoamine oxidases (MAO) and quercetin was the only compound with a selective inhibitory activity against MAO-A, with an IC50 value of 0.010 microM.