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Daniela Vullo
Researcher at University of Florence
Publications - 356
Citations - 15271
Daniela Vullo is an academic researcher from University of Florence. The author has contributed to research in topics: Carbonic anhydrase & Enzyme. The author has an hindex of 60, co-authored 342 publications receiving 13963 citations. Previous affiliations of Daniela Vullo include Canadian Institutes of Health Research & Griffith University.
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Journal ArticleDOI
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis
Fabio Pacchiano,Fabrizio Carta,Paul C. McDonald,Yuanmei Lou,Daniela Vullo,Andrea Scozzafava,Shoukat Dedhar,Shoukat Dedhar,Claudiu T. Supuran +8 more
TL;DR: One of them, 4-{[(3'-nitrophenyl)carbamoyl]amino}benzenesulfonamide, significantly inhibited the formation of metastases by the highly aggressive 4T1 mammary tumor cells at pharmacologic concentrations of 45 mg/kg, constituting an interesting candidate for the development of conceptually novel antimetastatic drugs.
Journal ArticleDOI
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum—The η-carbonic anhydrases
Sonia Del Prete,Daniela Vullo,Gillian M. Fisher,Katherine T. Andrews,Sally-Ann Poulsen,Clemente Capasso,Claudiu T. Supuran +6 more
TL;DR: The kinetic properties of PfCA for the CO2 hydration reaction, as well as an inhibition study of this enzyme with inorganic and complex anions and other molecules known to interact with zinc proteins, are demonstrated, detecting several low micromolar inhibitors.
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Carbonic anhydrase in the scleractinian coral stylophora pistillata: characterization, localization, and role in biomineralization
Aurelie Moya,Sylvie Tambutté,Anthony Bertucci,Eric Tambutté,Severine Lotto,Daniela Vullo,Claudiu T. Supuran,Denis Allemand,Didier Zoccola +8 more
TL;DR: STPCA is a secreted form of α-CA, which possesses a CA catalytic function, similar to the secreted human CAVI, and its localization at the calicoblastic ectoderm level supports the role of STPCA in the calcification process.
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Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Daniela Vullo,Alessio Innocenti,Isao Nishimori,Jaromir Pastorek,Andrea Scozzafava,Silvia Pastorekova,Claudiu T. Supuran +6 more
TL;DR: Apparently, hCA XII is a target of the antiglaucoma sulfonamides, and potent hCA XI inhibitors may be developed/used for the management of hypoxic tumors, together with inhibitors of the other tumor-associated isozyme, CA IX.
Journal ArticleDOI
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
Daniela Vullo,Marco Franchi,Enzo Gallori,Jaromir Pastorek,Andrea Scozzafava,Silvia Pastorekova,Claudiu T. Supuran +6 more
TL;DR: Because CA IX is a highly active isozyme predominantly expressed in tumor tissues with poor prognosis of disease progression, this finding is very promising for the potential design of CA IX-specific inhibitors with applications as anti-tumor agents.