D
Danny R. Welch
Researcher at University of Kansas
Publications - 281
Citations - 16612
Danny R. Welch is an academic researcher from University of Kansas. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 69, co-authored 260 publications receiving 15531 citations. Previous affiliations of Danny R. Welch include University of Arizona & Columbia University.
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Journal ArticleDOI
KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene
Jeong Hyung Lee,Mary E. Miele,Deana J. Hicks,Karen K. Phillips,Jeffery M. Trent,Bernard E. Weissman,Danny R. Welch +6 more
TL;DR: The results imply that mutations of genes on chromosome 6 are among those late genetic changes responsible for metastatic potential of malignant melanoma cells and suggest that KiSS-1 expression may be a useful marker for distinguishing metastatic melanoma from nonmetastatic melanomas.
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Metastasis: recent discoveries and novel treatment strategies
Suzanne A. Eccles,Danny R. Welch +1 more
TL;DR: This work focuses on recent findings regarding intrinsic and extrinsic molecular mechanisms controlling metastasis that determine how, when, and where cancers metastasise, and their implications for patient management in the 21st century.
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Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.
TL;DR: The results suggest that TGF-beta 1 may modulate metastatic potential of mammary tumor cells by controlling their ability to break down and penetrate basement-membrane barriers.
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Breast Cancer Metastasis Suppressor 1 Up-regulates miR-146, Which Suppresses Breast Cancer Metastasis
Douglas R. Hurst,Mick D. Edmonds,Gary K. Scott,Christopher C. Benz,Kedar S. Vaidya,Danny R. Welch +5 more
TL;DR: Results further support the recent notion that modulating the levels of miR-146a or miB-146b could have a therapeutic potential to suppress breast cancer metastasis.
Journal ArticleDOI
Defining the Hallmarks of Metastasis
Danny R. Welch,Douglas R. Hurst +1 more
TL;DR: By defining these first principles of metastasis, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues.