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Daqian Xu
Researcher at Chinese Academy of Sciences
Publications - 22
Citations - 698
Daqian Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Golgi apparatus & Phosphorylation. The author has an hindex of 12, co-authored 18 publications receiving 518 citations. Previous affiliations of Daqian Xu include University of Texas MD Anderson Cancer Center & Shanghai University.
Papers
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Journal ArticleDOI
AMPK regulates autophagy by phosphorylating BECN1 at threonine 388
Deyi Zhang,Wei Wang,Xiujie Sun,Daqian Xu,Chenyao Wang,Qian Zhang,Huafei Wang,Wenwen Luo,Yan Chen,Huaiyong Chen,Zhixue Liu +10 more
TL;DR: It is shown that AMP-activated protein kinase (AMPK) regulates autophagy by phosphorylating BECN1 at Thr388, uncovering a novel mechanism of Autophagy regulation.
Journal ArticleDOI
Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
Chenyao Wang,Huafei Wang,Deyi Zhang,Wenwen Luo,Ruilong Liu,Daqian Xu,Lei Diao,Lujian Liao,Zhixue Liu,Zhixue Liu +9 more
TL;DR: A late role for ULK in auotophagosome–lysosome fusion is demonstrated and the significance of the mutual regulation of macroautophagy and CMA in maintaining the balance of autophagy is revealed.
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PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus
TL;DR: PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis.
Journal ArticleDOI
Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice
Gaigai Liu,Y Zhang,Chunchun Liu,Daqian Xu,Rui Zhang,Yuan Cheng,Yi（潘怡） Pan,Cheng Huang,Yan（陈雁） Chen +8 more
TL;DR: Luteolin is effective in ameliorating ethanol-induced hepatic steatosis and injury and the transcriptional activity of the master regulator of lipid synthesis, sterol regulatory element-binding protein (SREBP), was enhanced by ethanol treatment and reduced by luteolin administration.
Journal ArticleDOI
PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L‐associated PI3K activity
Daqian Xu,Zheng Wang,Chenyao Wang,Deyi Zhang,Huida Wan,Zilong Zhao,Jin Gu,Yong‐Xian Zhang,Zhigang Li,Kaiyang Man,Yi Pan,Zhi‐Fei Wang,Zun-Ji Ke,Zhixue Liu,Lujian Liao,Yan Chen,Yan Chen +16 more
TL;DR: PAQR3 can not only enhance the capacity of pro‐autophagy class III PI3K due to its scaffold function, but also integrate AMPK signal to activation of ATG14L‐linked VPS34 complex upon glucose starvation.