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Darryl R. Overby
Researcher at Imperial College London
Publications - 103
Citations - 4896
Darryl R. Overby is an academic researcher from Imperial College London. The author has contributed to research in topics: Trabecular meshwork & Schlemm's canal. The author has an hindex of 38, co-authored 97 publications receiving 4001 citations. Previous affiliations of Darryl R. Overby include Royal School of Mines & Tulane University.
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Journal ArticleDOI
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels
TL;DR: Cell use multiple mechanisms to sense and respond to static and dynamic changes in the level of mechanical stress applied to integrins, and these responses differed biochemically.
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Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins
Benjamin D. Matthews,Charles K. Thodeti,Charles K. Thodeti,Jessica D. Tytell,Akiko Mammoto,Darryl R. Overby,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +8 more
TL;DR: It is shown that forces applied to beta1 integrins result in ultra-rapid activation of calcium influx through TRPV4 channels, which may enable compartmentalization of calcium signaling within focal adhesions that is critical for mechanical control of many cell behaviors that underlie cell and tissue development.
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The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium.
TL;DR: The "funneling" hypothesis that has emerged as a leading synergistic model is closely examined, and the basis of funneling, mechanical and biological requirements for funneling and evidence in support of this hypothesis are reviewed.
Journal ArticleDOI
Consensus recommendations for trabecular meshwork cell isolation, characterization and culture
Kate E. Keller,Sanjoy K. Bhattacharya,Theresa Borrás,Thomas M. Brunner,Sunee Chansangpetch,Abbott F. Clark,W. Michael Dismuke,Yiqin Du,Michael H. Elliott,C. Ross Ethier,Jennifer A. Faralli,Thomas F. Freddo,Rudolf Fuchshofer,Michael Giovingo,Haiyan Gong,Pedro Gonzalez,Alex S. Huang,Murray A. Johnstone,Paul L. Kaufman,Mary J. Kelley,Paul A. Knepper,Casey Kopczynski,John Kuchtey,Rachel W. Kuchtey,Markus H. Kuehn,Raquel L. Lieberman,Shan C. Lin,Paloma B. Liton,Yutao Liu,Elke Lütjen-Drecoll,Weiming Mao,Marisse Masis-Solano,Fiona McDonnell,Colleen M McDowell,Darryl R. Overby,Padmanabhan P. Pattabiraman,Vijay Krishna Raghunathan,P. Vasanth Rao,Douglas J Rhee,Uttio Roy Chowdhury,Paul Russell,John R. Samples,Donald Schwartz,Evan B. Stubbs,Ernst R. Tamm,James C. Tan,Carol B. Toris,Karen Y. Torrejon,Janice A. Vranka,Mary K. Wirtz,Thomas Yorio,Jie Zhang,Gulab Zode,Michael P. Fautsch,Donna M. Peters,Ted S. Acott,W. Daniel Stamer +56 more
TL;DR: Having a set of standard practices for TM cells will increase the scientific rigor when used as a model, and enable other researchers to replicate and build upon previous findings.
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Reduction of the Available Area for Aqueous Humor Outflow and Increase in Meshwork Herniations into Collector Channels Following Acute IOP Elevation in Bovine Eyes
Stephanie A. Battista,Zhaozeng Lu,Zhaozeng Lu,Sara Hofmann,Thomas F. Freddo,Darryl R. Overby,Haiyan Gong,Haiyan Gong +7 more
TL;DR: Low outflow facility during acute IOP elevation coincides with a reduction in available area for aqueous humor outflow and the confinement of outflow to the vicinity of CC ostia, likely driven by morphologic changes associated with AP collapse and herniation of IW of AP intoCC ostia.