Author
Daves Gd
Bio: Daves Gd is an academic researcher from Lehigh University. The author has an hindex of 1, co-authored 1 publications receiving 177 citations.
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TL;DR: This chapter reviews recent advances in the chemistry and biochemistry of C-nucleosides, the literature concerning C-arylglycoside (i.e., nonnitrogen heterocyclic C- nucleoside) antibiotics, and recent significant advances in The most frequently used strategy for C-methine synthesis involves the construction of a heterocyClic aglycone from the C-1 substituent of a functionalized sugar intermediate.
Abstract: Publisher Summary This chapter reviews recent advances in the chemistry and biochemistry of C-nucleosides, the literature concerning C-arylglycoside (i.e., nonnitrogen heterocyclic C-nucleoside) antibiotics, and recent significant advances in the synthesis of C-nucleosides and C-glycosides. It also discusses biological test data and data that are relevant to structure–activity relationships. Modification of readily available natural C-nucleosides is an attractive route to new C-nucleoside analogs and derivatives, because one starting material often possesses much of the desired functionality and chiral properties. The chapter illustrates this approach with examples. The most frequently used strategy for C-nucleoside synthesis involves the construction of a heterocyclic aglycone from the C-1 substituent of a functionalized sugar intermediate.
179 citations
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TL;DR: Some of the major applications of Minisci reactions and related processes to medicinal or biological chemistry are described, and some potential developments within this area are highlighted.
Abstract: The addition of a radical to a heteroaromatic base is commonly referred to as a Minsici reaction. Such reactions constitute a broad-set of selective CH-functionalization processes. This review describes some of the major applications of Minisci reactions and related processes to medicinal or biological chemistry, and highlights some potential developments within this area.
429 citations
388 citations
TL;DR: The focus of this review is to highlight the structure, bioactivity and biosynthesis of naturally occurring aryl-C-glycosides.
222 citations
TL;DR: Two new compounds, helicin (i.e. salicylaldehyde-β-d -glycoside) thiosemicarbazone monohydrate, Het·H2O (1), and bis[aqua(salicylalde thiOSEmicarbazonato)copper(II)]sulfate bisdimethylsulfoxide solvate hexahydrate [Cu(Hsalt)(OH2)]2SO4
178 citations
TL;DR: The aryl C-glycoside structure is, among the plenty of biologically active natural products, one of the distinct motifs embedded, and the synthetic strategies and tactics employed in the total synthesis of this class of natural products.
Abstract: The aryl C-glycoside structure is, among the plenty of biologically active natural products, one of the distinct motifs embedded. Because of the potential bioactivity as well as the synthetic challenges, these structures have attracted considerable interest, and extensive research toward the total synthesis has been performed. This Review focuses on the synthetic strategies and tactics employed in the total synthesis of this class of natural products. The Introduction describes the historical background, structural features, and synthetic problems associated with aryl C-glycoside natural products. Next the Review summarizes the methods for constructing the aryl C-glycoside bonds. Completed total syntheses—and, in some cases, selected examples of incomplete syntheses—of natural aryl C-glycosides are also summarized. Finally described are the strategies for constructing polycyclic structures, which were utilized in the total syntheses.
173 citations