David A. Gorelick

TL;DR: Growing evidence suggests that behavioral addictions resemble substance addictions in many domains, including natural history, phenomenology, tolerance, comorbidity, overlapping genetic contribution, neurobiological mechanisms, and response to treatment, supporting the DSM-V Task Force proposed new category of Addiction and Related Disorders encompassing both substance use disorders and non-substance addictions.

TL;DR: A comprehensive review, based on a systematic electronic literature search, of SC epidemiology and pharmacology and their clinical implications is presented, showing in vitro and animal in vivo studies show SC pharmacological effects 2-100 times more potent than THC.

TL;DR: These findings confirm, for the first time in humans, the central role of CB1 receptors in mediating the effects of marijuana.

TL;DR: Findings demonstrate for the first time the involvement of the endogenous opioid system in cocaine dependence and cocaine craving in living human subjects.

TL;DR: A high percentage of seriously injured trauma center patients are at risk of having current PSUDs, and patients with positive toxicology screening test results and/or positive screening questionnaire responses should be referred for formal evaluation and treatment.