D
David A. Lewis
Researcher at University of Pittsburgh
Publications - 617
Citations - 60508
David A. Lewis is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Prefrontal cortex & Dorsolateral prefrontal cortex. The author has an hindex of 120, co-authored 562 publications receiving 54796 citations. Previous affiliations of David A. Lewis include Scripps Research Institute & Northwestern University.
Papers
More filters
Journal ArticleDOI
Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
Journal ArticleDOI
Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.
Leisa A. Glantz,David A. Lewis +1 more
TL;DR: This region- and disease-specific decrease in dendritic spine density on dorsolateral prefrontal cortex layer 3 pyramidal cells is consistent with the hypothesis that the number of cortical and/or thalamic excitatory inputs to these neurons is altered in subjects with schizophrenia.
Journal ArticleDOI
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
Giorgio A. Ascoli,Lidia Alonso-Nanclares,Stewart A. Anderson,German Barrionuevo,Ruth Benavides-Piccione,Andreas Burkhalter,György Buzsáki,Bruno Cauli,Javier DeFelipe,Alfonso Fairén,Dirk Feldmeyer,Gord Fishell,Yves Frégnac,Tamás F. Freund,Daniel Gardner,Esther P. Gardner,Jesse H. Goldberg,Moritz Helmstaedter,Shaul Hestrin,Fuyuki Karube,Zoltán F. Kisvárday,Bertrand Lambolez,David A. Lewis,Oscar Marín,Henry Markram,Alberto Muñoz,Adam M. Packer,Carl C.H. Petersen,Kathleen S. Rockland,Jean Rossier,Bernardo Rudy,Peter Somogyi,Jochen F. Staiger,Gábor Tamás,Alex M. Thomson,Maria Toledo-Rodriguez,Yun Wang,David C. West,Rafael Yuste +38 more
TL;DR: A representative group of researchers are convened to agree on a set of terms to describe the anatomical, physiological and molecular features of GABAergic interneurons of the cerebral cortex, and the resulting terminology might provide a stepping stone towards a future classification of these complex and heterogeneous cells.
Journal ArticleDOI
Schizophrenia as a Disorder of Neurodevelopment
David A. Lewis,Pat Levitt +1 more
TL;DR: These findings suggest that combinatorial genetic and environmental factors, which disturb a normal developmental course early in life, result in molecular and histogenic responses that cumulatively lead to different developmental trajectories and the clinical phenotype recognized as schizophrenia.
Journal ArticleDOI
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
TL;DR: A new model of cortical dysfunction in schizophrenia is suggested in which PVBC inhibition is decreased to compensate for an upstream deficit in pyramidal cell excitation, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control.