D
David A. Sweetser
Researcher at Harvard University
Publications - 108
Citations - 5094
David A. Sweetser is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 32, co-authored 92 publications receiving 4212 citations. Previous affiliations of David A. Sweetser include Howard Hughes Medical Institute & Washington University in St. Louis.
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Journal ArticleDOI
Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
Soheil Meshinchi,William G. Woods,Derek L. Stirewalt,David A. Sweetser,Jonathan D. Buckley,Thomas K. Tjoa,Irwin D. Bernstein,Jerald P. Radich +7 more
TL;DR: Diagnostic bone marrow specimens from 91 pediatric patients with AML were analyzed for the presence of the Flt3/ITD and its presence was the single most significant, independent prognostic factor for poor outcome in pediatric AML.
Journal ArticleDOI
The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships.
David A. Sweetser,E H Birkenmeier,I J Klisak,S Zollman,R S Sparkes,T Mohandas,A J Lusis,Jeffrey I. Gordon +7 more
TL;DR: The nucleotide sequence of the gene encoding human I-FABP is determined and the primary structure of its protein product is defined and it is indicated that I-fABP mRNA is confined to the intestine.
Journal ArticleDOI
The Metabolic Significance of Mammalian Fatty-Acid-Binding Proteins: Abundant Proteins in Search of a Function
Journal ArticleDOI
Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease
Kimberly Splinter,David R. Adams,Carlos A. Bacino,Hugo J. Bellen,Jonathan A. Bernstein,Alys M. Cheatle-Jarvela,Christine M. Eng,Cecilia Esteves,William A. Gahl,Rizwan Hamid,Howard J. Jacob,Bijal Kikani,David M. Koeller,Isaac S. Kohane,Brendan Lee,Joseph Loscalzo,Xi Luo,Alexa T. McCray,Thomas O. Metz,John J. Mulvihill,Stanley F. Nelson,Christina G.S. Palmer,John A. Phillips,Leslie Pick,John H. Postlethwait,Chloe M. Reuter,Vandana Shashi,David A. Sweetser,Cynthia J. Tifft,Nicole M. Walley,Michael F. Wangler,Monte Westerfield,Matthew T. Wheeler,Anastasia L. Wise,Elizabeth A. Worthey,Shinya Yamamoto,Euan A. Ashley +36 more
TL;DR: The rate of diagnosis among patients who subsequently had a complete evaluation was determined, the effect of diagnosis on medical care was observed, and 31 new syndromes were defined.
Journal ArticleDOI
Panel-based genetic diagnostic testing for inherited eye diseases is highly accurate and reproducible, and more sensitive for variant detection, than exome sequencing
Mark Consugar,Daniel Navarro-Gomez,Emily Place,Kinga M. Bujakowska,Maria E. Sousa,Zoe Fonseca-Kelly,Daniel G. Taub,Maria Janessian,Dan Yi Wang,Elizabeth D. Au,Katherine B. Sims,David A. Sweetser,Anne B. Fulton,Qin Liu,Janey L. Wiggs,Xiaowu Gai,Eric A. Pierce +16 more
TL;DR: Based on quantified performance metrics, the data suggest that selective targeted enrichment is preferable to whole-exome sequencing for genetic diagnostic testing of patients with inherited eye disorders.