David A. Tirrell

TL;DR: New challenges and directions in biomaterials research are discussed, including synthetic replacements for biological tissues, designing materials for specific medical applications, and materials for new applications such as diagnostics and array technologies.

TL;DR: The mild conditions under which gel formation can be controlled suggest that artificial proteins that undergo reversible gelation in response to changes in pH or temperature have potential in bioengineering applications requiring encapsulation or controlled release of molecular and cellular species.

TL;DR: It is shown that proteins containing azidohomoalanine can be selectively modified in the presence of other cellular proteins by means of Staudinger ligation with triarylphosphine reagents and incorporation of azide-functionalized amino acids into proteins in vivo provides opportunities for protein modification under native conditions and selective labeling of proteins in the intracellular environment.

TL;DR: In this paper, the authors used a sensitive solution microcalorimeter to study lower critical solution temperatures (LCSTs) of aqueous polymer solutions and found that the LCST of poly(N-isopropylacrylamide) (PNIPAAM), poly(vinyl methyl ether) (PVME), and poly(propylene glycol)(PPG), and hydroxypropylcelluloe (HPC) was found to be dependent on the chain length, generally increasing with decreasing M-bar_n in the range M-

TL;DR: This paper reports the selective purification and identification of 195 metabolically labeled proteins with multidimensional liquid chromatography in-line with tandem MS and says the identified proteins, synthesized in a 2-h window, possess a broad range of biochemical properties and span most functional gene ontology categories.