D
David Allsop
Researcher at Lancaster University
Publications - 164
Citations - 13635
David Allsop is an academic researcher from Lancaster University. The author has contributed to research in topics: Senile plaques & Amyloid. The author has an hindex of 53, co-authored 161 publications receiving 12362 citations. Previous affiliations of David Allsop include University of Nottingham & St. George's University.
Papers
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Journal ArticleDOI
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
John Hardy,David Allsop +1 more
TL;DR: The recent discovery of a pathogenic mutation in the beta-amyloid precursor protein (APP) gene on chromosome 21 suggests that APP Mismetabolism and beta-amide deposition are the primary events in the disease process.
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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.
Tobias Hartmann,Sophie Bieger,Babara Brühl,Pentti J. Tienari,Nobuo Ida,David Allsop,Gareth W. Roberts,Colin L. Masters,Carlos G. Dotti,Klaus Unsicker,Konrad Beyreuther +10 more
TL;DR: The specific production of the critical Aβ isoform in the ER of neurons links this compartment with the generation of Aβ and explains why primarily ER localized (mutant) proteins such as the presenilins3 could induce AD.
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Magnetite pollution nanoparticles in the human brain.
Barbara A. Maher,Imad A. M. Ahmed,Vassil Karloukovski,Donald A. MacLaren,Penelope G. Foulds,David Allsop,David M. A. Mann,Ricardo Torres-Jardón,Lilian Calderón-Garcidueñas +8 more
TL;DR: Kirschvink et al. as discussed by the authors used magnetic analyses and electron microscopy to identify the abundant presence in the brain of magnetite nanoparticles that are consistent with high-temperature formation, suggesting, therefore, an external, not internal, source.
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Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson’s disease
Omar M. A. El-Agnaf,Sultan A. Salem,Katerina E. Paleologou,Martin D. Curran,Mark J. Gibson,Jennifer A. Court,Jennifer A. Court,Michael G. Schlossmacher,Michael G. Schlossmacher,David Allsop +9 more
TL;DR: A novel ELISA method is developed that detects only oligomeric “soluble aggregates” of α‐syn in human plasma as a potential biomarker for Parkinson's disease and offers new opportunities for developing diagnostic tests for PD and related diseases.
Journal ArticleDOI
α-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
Omar M. A. El-Agnaf,Sultan A. Salem,Katerina E. Paleologou,Leanne J. Cooper,Nigel J. Fullwood,Mark J. Gibson,Martin D. Curran,Jennifer A. Court,David M. A. Mann,Shu-ichi Ikeda,Mark R. Cookson,John Hardy,David Allsop +12 more
TL;DR: The findings suggest that cells normally secrete α‐syn into their surrounding media, both in vitro and in vivo, and the detection of extracellular α‐ syn and/or its modified forms in body fluids, particularly in human plasma, offers new opportunities for the development of diagnostic tests for PD.