D
David Altshuler
Researcher at University of Michigan
Publications - 353
Citations - 226195
David Altshuler is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 162, co-authored 345 publications receiving 201782 citations. Previous affiliations of David Altshuler include Vertex Pharmaceuticals & Massachusetts Institute of Technology.
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Journal ArticleDOI
New susceptibility locus for coronary artery disease on chromosome 3q22.3
Jeanette Erdmann,Anika Großhennig,Peter S. Braund,Inke R. König,Christian Hengstenberg,Alistair S. Hall,Patrick Linsel-Nitschke,Sekar Kathiresan,Ben J Wright,David-Alexandre Trégouët,François Cambien,Petra Bruse,Zouhair Aherrahrou,Arnika Kathleen Wagner,Klaus Stark,Stephen M. Schwartz,Veikko Salomaa,Roberto Elosua,Olle Melander,Benjamin F. Voight,Christopher J. O'Donnell,Leena Peltonen,David S. Siscovick,David Altshuler,Piera Angelica Merlini,Flora Peyvandi,Luisa Bernardinelli,Luisa Bernardinelli,Diego Ardissino,Arne Schillert,Stefan Blankenberg,Tanja Zeller,Philipp S. Wild,Daniel F Schwarz,Laurence Tiret,Claire Perret,Stefan Schreiber,Nour Eddine El Mokhtari,Arne Schäfer,Winfried März,Winfried März,Winfried März,Wilfried Renner,Peter Bugert,Harald Klüter,Jürgen Schrezenmeir,Diana Rubin,Stephen G. Ball,Anthony J. Balmforth,H-Erich Wichmann,Thomas Meitinger,Marcus Fischer,Christa Meisinger,Jens Baumert,Annette Peters,Willem H. Ouwehand,Panos Deloukas,John R. Thompson,Andreas Ziegler,Nilesh J. Samani,Heribert Schunkert +60 more
TL;DR: A three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls is presented and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 is identified.
Journal ArticleDOI
The role of PPAR-γ in macrophage differentiation and cholesterol uptake
Kathryn J. Moore,Evan D. Rosen,Michael L. Fitzgerald,Felix Randow,Lorna P. Andersson,David Altshuler,David Altshuler,David S. Milstone,David S. Milstone,Richard M. Mortensen,Bruce M. Spiegelman,Mason W. Freeman +11 more
TL;DR: In wild-type macrophages, TZD treatment divergently regulated CD36 and class A macrophage-scavenger receptor expression and failed to induce significant cellular cholesterol accumulation, indicating that TZDs may not exacerbate Macrophage foam-cell formation.
Journal ArticleDOI
Whole population, genome-wide mapping of hidden relatedness
Alexander Gusev,Jennifer K. Lowe,Markus Stoffel,Mark J. Daly,David Altshuler,Jan L. Breslow,Jeffrey M. Friedman,Itsik Pe'er +7 more
TL;DR: This work uses GERMLINE, a robust algorithm for identifying segmental sharing indicative of recent common ancestry between pairs of individuals, to comprehensively survey hidden relatedness both in the HapMap as well as in a densely typed island population of 3000 individuals.
Journal ArticleDOI
Methods for high-density admixture mapping of disease genes.
Nick Patterson,Neil Hattangadi,Barton Lane,Kirk E. Lohmueller,David A. Hafler,David A. Hafler,David A. Hafler,Jorge R. Oksenberg,Stephen L. Hauser,Michael W. Smith,Michael W. Smith,Stephen J. O'Brien,David Altshuler,Mark J. Daly,Mark J. Daly,David Reich,David Reich +16 more
TL;DR: In this paper, the authors proposed a statistical method to estimate the ancestral origin of a locus on the basis of the composite genotypes of linked markers, and showed that this approach accurately estimates states of ancestral origin along the genome.
Journal ArticleDOI
A High-Density Admixture Map for Disease Gene Discovery in African Americans
Michael W. Smith,Michael W. Smith,Nick Patterson,James A. Lautenberger,Ann L. Truelove,Ann L. Truelove,Gavin J. McDonald,Gavin J. McDonald,Alicja Waliszewska,Alicja Waliszewska,Alicja Waliszewska,Bailey Kessing,Bailey Kessing,Michael Malasky,Michael Malasky,Charles R. Scafe,Ernest Le,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Andre A. Mignault,Zeng Yi,Myron Essex,J L Sankalé,Jason H. Moore,Kwabena A. Poku,J. P. Phair,James J. Goedert,David Vlahov,Scott M. Williams,Sarah A. Tishkoff,Cheryl A. Winkler,Cheryl A. Winkler,Francisco M. De La Vega,Trevor Woodage,John J. Sninsky,David A. Hafler,David A. Hafler,David A. Hafler,David Altshuler,Dennis A. Gilbert,Stephen J. O'Brien,David Reich,David Reich +43 more
TL;DR: This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts, and is especially appropriate for those diseases that differ in incidence between the parental African and European populations.