D
David Altshuler
Researcher at University of Michigan
Publications - 353
Citations - 226195
David Altshuler is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 162, co-authored 345 publications receiving 201782 citations. Previous affiliations of David Altshuler include Vertex Pharmaceuticals & Massachusetts Institute of Technology.
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Journal ArticleDOI
The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease
Loukas Moutsianas,Vineeta Agarwala,Vineeta Agarwala,Christian Fuchsberger,Jason Flannick,Jason Flannick,Manuel A. Rivas,Kyle J. Gaulton,Patrick K. Albers,Gil McVean,Michael Boehnke,David Altshuler,Mark I. McCarthy +12 more
TL;DR: The results imply that tens of thousands of individuals, extensive functional annotation, or highly targeted hypothesis testing will be required to confidently detect or exclude rare variant signals at complex disease loci.
Journal ArticleDOI
Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.
Jose C. Florez,Kathleen A. Jablonski,Maria W. Sun,Maria W. Sun,Nick Bayley,Nick Bayley,Steven E. Kahn,Harry Shamoon,Richard F. Hamman,William C. Knowler,David M. Nathan,David Altshuler +11 more
TL;DR: The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index.
Journal ArticleDOI
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Anders Albrechtsen,Niels Grarup,Yun Li,Thomas Sparsø,G. Tian,H. Cao,T. Jiang,S. Y. Kim,Thorfinn Sand Korneliussen,Q. Li,Chao Nie,R. Wu,Line Skotte,Andrew P. Morris,Claes Ladenvall,Stéphane Cauchi,Alena Stančáková,Gregers S. Andersen,Arne Astrup,Karina Banasik,Amanda J. Bennett,Lars Bolund,Guillaume Charpentier,Yi Chen,J. M. Dekker,Alex S. F. Doney,Mozhgan Dorkhan,Tom Forsén,Timothy M. Frayling,Christopher J. Groves,Y. Gui,Göran Hallmans,Andrew T. Hattersley,Kunlun He,Graham A. Hitman,Johan Holmkvist,S. Huang,H. Jiang,Xin Jin,Johanne Marie Justesen,Karsten Kristiansen,Johanna Kuusisto,Maria Lajer,Olivier Lantieri,Weijing Li,H. Liang,Q. Liao,X. Liu,T. Ma,X. Ma,M. P. Manijak,Michel Marre,Michel Marre,Jacek Mokrosinski,Andrew D. Morris,B. Mu,Aneta Aleksandra Nielsen,Giel Nijpels,Peter M. Nilsson,Colin N. A. Palmer,Nigel W. Rayner,Nigel W. Rayner,Frida Renström,Rasmus Ribel-Madsen,Neil Robertson,Neil Robertson,Olov Rolandsson,Peter Rossing,Thue W. Schwartz,P.E. Slagboom,Maria Sterner,M. Tang,Lise Tarnow,Tiinamaija Tuomi,E. van 't Riet,N. van Leeuwen,Tibor V. Varga,Marie A. Vestmar,Mark Walker,B. Wang,Y. Wang,H. Wu,F. Xi,Loic Yengo,Chang Yu,Xiaoming Zhang,J. Zhang,Q. Zhang,Weihua Zhang,H. Zheng,Y. Zhou,David Altshuler,David Altshuler,Leen M 't Hart,Paul W. Franks,Paul W. Franks,Paul W. Franks,B. Balkau,Philippe Froguel,Philippe Froguel,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Markku Laakso,Leif Groop,Cramer Christensen,Ivan Brandslund,Torsten Lauritzen,Daniel R. Witte,Allan Linneberg,Torben Jørgensen,Torben Jørgensen,Torben Jørgensen,Torben Hansen,Torben Hansen,Jun Wang,Rasmus Nielsen,Rasmus Nielsen,Oluf Pedersen +118 more
TL;DR: Exome sequencing is applied as a basis for finding genetic determinants of metabolic traits and show the existence of low-frequency and common coding polymorphisms with impact on common metabolic traits.
Journal ArticleDOI
IGF2BP2/IMP2 Deficient Mice Resist Obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding Mitochondrial Proteins
Ning Dai,Liping Zhao,Diedra M. Wrighting,Diedra M. Wrighting,Dana Kramer,Amit R. Majithia,Yanqun Wang,Valentin Cracan,Diego Borges-Rivera,Diego Borges-Rivera,Vamsi K. Mootha,Matthias Nahrendorf,David R. Thorburn,David R. Thorburn,Liliana Minichiello,David Altshuler,Joseph Avruch +16 more
TL;DR: IMP2 limits longevity and regulates nutrient and energy metabolism in the mouse by controlling the translation of its client mRNAs.
Journal ArticleDOI
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity
Christina L. Usher,Robert E. Handsaker,Tõnu Esko,Marcus A. Tuke,Michael N. Weedon,Alex Hastie,Han Cao,Jennifer E. Moon,Seva Kashin,Christian Fuchsberger,Andres Metspalu,Carlos N. Pato,Michele T. Pato,Mark I. McCarthy,Michael Boehnke,David Altshuler,Timothy M. Frayling,Joel N. Hirschhorn,Steven A. McCarroll +18 more
TL;DR: It is found that the AMY1 copy number in an individual's genome is generally even (rather than odd) and partially correlates with nearby SNPs, which do not associate with body mass index (BMI).