D
David Altshuler
Researcher at University of Michigan
Publications - 353
Citations - 226195
David Altshuler is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 162, co-authored 345 publications receiving 201782 citations. Previous affiliations of David Altshuler include Vertex Pharmaceuticals & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans
Katharine R. Clapham,Audrey Y. Chu,Audrey Y. Chu,Jennifer Wessel,Pradeep Natarajan,Jason Flannick,Jason Flannick,Manuel A. Rivas,Manuel A. Rivas,Samantha Sartori,Roxana Mehran,Usman Baber,Valentin Fuster,Robert A. Scott,Daniel J. Rader,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,David Altshuler,David Altshuler,Sekar Kathiresan,Gina M. Peloso +22 more
TL;DR: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance, and its association with fasting glucose levels and risk for type 2 diabetes is found to be insignificant.
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
Victor Rusu,Eitan Hoch,Josep M. Mercader,Danielle Tenen,Melissa Gymrek,Christina R. Hartigan,Michael DeRan,Marcin von Grotthuss,Pierre Fontanillas,Alexandra Spooner,Gaelen Guzman,Amy Deik,Kerry A. Pierce,Courtney Dennis,Clary B. Clish,Steven A. Carr,Bridget K. Wagner,Monica Schenone,Maggie C.Y. Ng,Brian H. Chen,Federico Centeno-Cruz,Carlos Zerrweck,Lorena Orozco,David M. Altshuler,Stuart L. Schreiber,Jose C. Florez,Suzanne B.R. Jacobs,Eric S. Lander,Daniel Shriner,Jiang Li,Wei-Min Chen,Xiuqing Guo,Jiankang Liu,Suzette J. Bielinski,Lisa R. Yanek,Mike A. Nalls,Mary E. Comeau,Laura J. Rasmussen-Torvik,Richard A. Jensen,Daniel S. Evans,Yan V. Sun,Ping An,Sanjay R. Patel,Yingchang Lu,Jirong Long,Loren L. Armstrong,Lynne E. Wagenknecht,Lingyao Yang,Beverly M. Snively,Nicholette D. Palmer,Poorva Mudgal,Carl D. Langefeld,Keith L. Keene,Barry I. Freedman,Josyf C. Mychaleckyj,Uma Nayak,Leslie J. Raffel,Mark O. Goodarzi,Y. D.I. Chen,Herman A. Taylor,Adolfo Correa,Mario Sims,David Couper,James S. Pankow,Eric Boerwinkle,Adebowale Adeyemo,Ayo P. Doumatey,Guanjie Chen,Rasika A. Mathias,Dhananjay Vaidya,Andrew B. Singleton,Alan B. Zonderman,Robert P. Igo,John R. Sedor,Edmond K. Kabagambe,David S. Siscovick,Barbara McKnight,Kenneth Rice,Yongmei Liu,Wen-Chi Hsueh,Wei Zhao,Lawrence F. Bielak,Aldi T. Kraja,Michael A. Province,Erwin P. Bottinger,Omri Gottesman,Qiuyin Cai,Wei Zheng,William J. Blot,William L. Lowe,Jennifer A. Pacheco,Dana C. Crawford,Elin Grundberg,Stephen S. Rich,M. Geoffrey Hayes,Xiao-Ou Shu,Ruth J. F. Loos,Ingrid B. Borecki,Patricia A. Peyser,Steven R. Cummings,Bruce M. Psaty,Myriam Fornage,Sudha K. Iyengar,Michele K. Evans,Diane M. Becker,W. H. Linda Kao,James G. Wilson,Jerome I. Rotter,Michèle M. Sale,Simin Liu,Charles N. Rotimi,Donald W. Bowden,Alicia Huerta-Chagoya,Humberto García-Ortiz,Hortensia Moreno-Macías,Alisa K. Manning,Lizz Caulkins,Noël P. Burtt,Jason Flannick,Nick Patterson,Carlos A. Aguilar-Salinas,Teresa Tusié-Luna,David Altshuler,Angélica Martínez-Hernández,Francisco Barajas-Olmos,Cecilia Contreras-Cubas,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Cordova,Xavier Soberón,Clicerio González-Villalpando,María Elena González-Villalpando,Christopher A. Haiman,Lynne R. Wilkens,Loic Le Marchand,Kristine R. Monroe,Laurence N. Kolonel,Olimpia Arellano-Campos,María Luisa Ordóñez-Sánchez,Maribel Rodríguez-Torres,Yayoi Segura-Kato,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Linda Liliana Muñoz-Hernandez,Tamara Sáenz,Donají Gómez,Ulices Alvirde,Paloma Almeda-Valdes,Maria L. Cortes +149 more
Patent
Haplotype map of the human genome and uses therefor
Mark J. Daly,David Altshuler,Eric S. Lander,John D. Rioux,Stacey Gabriel,Stephen F. Schaffner +5 more
TL;DR: A method of producing a haplotype map which can be used to select an optimal set of single nucleotide polymorphic sites for examination in a subsequent genotyping study is disclosed in this paper.
Patent
Pre-selection and isolation of single nucleotide polymorphisms
TL;DR: In this paper, a method for reproducibly determining a limited population of polymorphisms is described. But this method requires a large number of nodes to be present in each node.
Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae
Jennifer K. Lowe,Jennifer K. Lowe,Jennifer K. Lowe,Julian Maller,Julian Maller,Itsik Pe'er,Itsik Pe'er,Benjamin M. Neale,Benjamin M. Neale,Benjamin M. Neale,Jacqueline Salit,Eimear E. Kenny,Jessica Shea,Jessica Shea,Ralph Burkhardt,J. Gustav Smith,Weizhen Ji,Martha Noel,Jia Nee Foo,Maude L. Blundell,Vita Skilling,Laura Garcia,Marcia L. Sullivan,Heather E. Lee,Anna Labek,Hope Ferdowsian,Steven B. Auerbach,Richard P. Lifton,Richard P. Lifton,Christopher Newton-Cheh,Jan L. Breslow,Markus Stoffel,Mark J. Daly,Mark J. Daly,David Altshuler,Jeffrey M. Friedman,Jeffrey M. Friedman +36 more
TL;DR: This study performed genome-wide association analysis for 15 quantitative traits in 2,906 members of the Kosrae population, using novel approaches to manage the extreme relatedness in the sample, and shows that the study is well powered to detect common alleles explaining ≥5% phenotypic variance.